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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SLC26A5 All Species: 26.97
Human Site: Y74 Identified Species: 53.94
UniProt: P58743 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P58743 NP_945350.1 744 81264 Y74 I T K W L P A Y K F K E Y V L
Chimpanzee Pan troglodytes XP_001145955 504 54853
Rhesus Macaque Macaca mulatta XP_001084716 505 55044
Dog Lupus familis XP_540393 744 81203 Y74 I T K W L P A Y K F K E Y V L
Cat Felis silvestris
Mouse Mus musculus Q99NH7 744 81302 Y74 I T K W L P A Y K F K E Y V L
Rat Rattus norvegicus Q9EPH0 744 81260 Y74 I T K W L P A Y K F K E Y V L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507963 744 81520 Y74 I C K W L P A Y K P R E Y I V
Chicken Gallus gallus NP_001072945 742 81094 Y75 I L K W L P R Y P V K E Y L L
Frog Xenopus laevis NP_001086349 726 79928 Y71 I L L W L P R Y P V K E W L L
Zebra Danio Brachydanio rerio NP_958881 739 81386 Y75 I L T W L P S Y P L K E Y L F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q94225 782 87457 G107 S F L Y I F F G T S K H N A L
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FY46 685 75077 M70 W T A K I K R M R L V D W I D
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 67.6 67.6 96.7 N.A. 94.8 94.4 N.A. 77.6 58.7 43.1 52.8 N.A. N.A. N.A. 26.4 N.A.
Protein Similarity: 100 67.7 67.7 98.3 N.A. 97.5 97.4 N.A. 87.5 75.8 60.6 69.8 N.A. N.A. N.A. 47.5 N.A.
P-Site Identity: 100 0 0 100 N.A. 100 100 N.A. 66.6 66.6 53.3 53.3 N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: 100 0 0 100 N.A. 100 100 N.A. 86.6 73.3 66.6 66.6 N.A. N.A. N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 28.4 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 49.3 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 40 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 9 0 0 0 42 0 0 0 0 0 0 9 0 % A
% Cys: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 9 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 67 0 0 0 % E
% Phe: 0 9 0 0 0 9 9 0 0 34 0 0 0 0 9 % F
% Gly: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % H
% Ile: 67 0 0 0 17 0 0 0 0 0 0 0 0 17 0 % I
% Lys: 0 0 50 9 0 9 0 0 42 0 67 0 0 0 0 % K
% Leu: 0 25 17 0 67 0 0 0 0 17 0 0 0 25 59 % L
% Met: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % N
% Pro: 0 0 0 0 0 67 0 0 25 9 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 25 0 9 0 9 0 0 0 0 % R
% Ser: 9 0 0 0 0 0 9 0 0 9 0 0 0 0 0 % S
% Thr: 0 42 9 0 0 0 0 0 9 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 17 9 0 0 34 9 % V
% Trp: 9 0 0 67 0 0 0 0 0 0 0 0 17 0 0 % W
% Tyr: 0 0 0 9 0 0 0 67 0 0 0 0 59 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _