Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TPI1 All Species: 57.88
Human Site: Y209 Identified Species: 84.89
UniProt: P60174 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P60174 NP_000356.1 249 26669 Y209 A Q S T R I I Y G G S V T G A
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta P15426 249 26692 Y209 A Q S T R I I Y G G S V T G A
Dog Lupus familis XP_534904 249 26696 Y209 A Q S T R I I Y G G S V T G A
Cat Felis silvestris
Mouse Mus musculus P17751 249 26694 Y209 A Q S T R I I Y G G S V T G A
Rat Rattus norvegicus P48500 249 26830 Y209 A Q C T R I I Y G G S V T G A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P00940 248 26602 Y208 A Q S T R I I Y G G S V T G G
Frog Xenopus laevis Q7ZWN5 248 26743 Y208 A Q S V R I I Y G G S V T G G
Zebra Danio Brachydanio rerio Q90XG0 248 26809 Y208 A N S V R I I Y G G S V T G G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P29613 247 26607 Y207 S A S L R I Q Y G G S V T A A
Honey Bee Apis mellifera NP_001090623 247 26880 Y207 A E T V R I I Y G G S V T A G
Nematode Worm Caenorhab. elegans Q10657 247 26556 Y207 A D A T R I I Y G G S V T A D
Sea Urchin Strong. purpuratus NP_001116981 250 26829 Y209 A A N T R I V Y G G S V N G G
Poplar Tree Populus trichocarpa
Maize Zea mays P12863 253 27006 Y209 A E S T R I I Y G G S V T A A
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SKP6 315 33327 Y268 A S K T R I I Y G G S V N G G
Baker's Yeast Sacchar. cerevisiae P00942 248 26777 Y208 A S E L R I L Y G G S A N G S
Red Bread Mold Neurospora crassa Q7S2Z9 248 27215 Y208 A E E T R I L Y G G S V N A K
Conservation
Percent
Protein Identity: 100 N.A. 99.1 98.3 N.A. 95.9 94.3 N.A. N.A. 89.5 83.5 82.7 N.A. 64.2 63 61.8 63.2
Protein Similarity: 100 N.A. 100 99.1 N.A. 97.5 96.3 N.A. N.A. 91.9 91.5 87.9 N.A. 75 76.3 73.4 76
P-Site Identity: 100 N.A. 100 100 N.A. 100 93.3 N.A. N.A. 93.3 86.6 80 N.A. 66.6 66.6 73.3 66.6
P-Site Similarity: 100 N.A. 100 100 N.A. 100 93.3 N.A. N.A. 93.3 86.6 80 N.A. 73.3 80 80 80
Percent
Protein Identity: N.A. 62 N.A. 50.1 53.4 57.8
Protein Similarity: N.A. 75.1 N.A. 58.7 67.8 69.4
P-Site Identity: N.A. 86.6 N.A. 73.3 53.3 60
P-Site Similarity: N.A. 93.3 N.A. 73.3 66.6 73.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 94 13 7 0 0 0 0 0 0 0 0 7 0 32 44 % A
% Cys: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 7 % D
% Glu: 0 19 13 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 100 100 0 0 0 69 38 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 100 75 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 7 % K
% Leu: 0 0 0 13 0 0 13 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 7 7 0 0 0 0 0 0 0 0 0 25 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 44 0 0 0 0 7 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 7 13 57 0 0 0 0 0 0 0 100 0 0 0 7 % S
% Thr: 0 0 7 69 0 0 0 0 0 0 0 0 75 0 0 % T
% Val: 0 0 0 19 0 0 7 0 0 0 0 94 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _