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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3E
All Species:
25.15
Human Site:
S168
Identified Species:
46.11
UniProt:
P60228
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P60228
NP_001559.1
445
52221
S168
T
D
R
N
A
L
S
S
L
W
G
K
L
A
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001090244
396
46427
S153
T
I
D
N
N
S
V
S
S
P
L
Q
S
L
Q
Dog
Lupus familis
XP_860062
352
41339
S109
T
I
D
N
N
S
V
S
S
P
L
Q
S
L
Q
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
XP_002727410
445
52210
S168
T
D
R
N
A
L
S
S
L
W
G
K
L
A
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505745
451
52629
S174
T
D
R
N
A
L
S
S
L
W
G
K
L
A
S
Chicken
Gallus gallus
Q5ZLA5
445
52117
S168
T
D
R
N
A
L
S
S
L
W
G
K
L
A
S
Frog
Xenopus laevis
Q3B8M3
446
52223
S169
T
D
R
N
A
L
S
S
L
W
G
K
L
A
S
Zebra Danio
Brachydanio rerio
Q1LUA8
446
52584
S169
T
D
R
N
A
L
S
S
L
W
G
K
L
A
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O77410
435
51144
V166
N
D
K
N
Y
L
N
V
L
W
G
K
L
A
A
Honey Bee
Apis mellifera
XP_623637
451
52726
V169
T
D
K
N
Y
L
N
V
L
W
G
K
L
A
S
Nematode Worm
Caenorhab. elegans
O61820
432
50701
A168
A
D
P
N
Y
L
N
A
L
Y
G
K
L
A
S
Sea Urchin
Strong. purpuratus
XP_001193661
398
46711
P155
D
P
S
H
F
I
T
P
L
Q
S
L
Q
Q
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7S519
443
51032
A184
D
N
D
K
V
S
Y
A
T
W
G
R
L
A
C
Conservation
Percent
Protein Identity:
100
N.A.
88.9
79
N.A.
N.A.
99
N.A.
92.9
97.5
95.7
93.7
N.A.
59
58.9
49.4
63.3
Protein Similarity:
100
N.A.
88.9
79
N.A.
N.A.
99
N.A.
93.7
99.5
98.4
98.2
N.A.
76.1
76.2
69.4
73.7
P-Site Identity:
100
N.A.
20
20
N.A.
N.A.
100
N.A.
100
100
100
100
N.A.
60
73.3
60
6.6
P-Site Similarity:
100
N.A.
26.6
26.6
N.A.
N.A.
100
N.A.
100
100
100
100
N.A.
80
86.6
80
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
41.8
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
63.3
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
26.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
46.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
47
0
0
16
0
0
0
0
0
77
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
16
70
24
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
77
0
0
0
0
% G
% His:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
16
0
0
0
8
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
16
8
0
0
0
0
0
0
0
70
0
0
0
% K
% Leu:
0
0
0
0
0
70
0
0
77
0
16
8
77
16
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
8
0
85
16
0
24
0
0
0
0
0
0
0
0
% N
% Pro:
0
8
8
0
0
0
0
8
0
16
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
8
0
16
8
8
16
% Q
% Arg:
0
0
47
0
0
0
0
0
0
0
0
8
0
0
8
% R
% Ser:
0
0
8
0
0
24
47
62
16
0
8
0
16
0
62
% S
% Thr:
70
0
0
0
0
0
8
0
8
0
0
0
0
0
0
% T
% Val:
0
0
0
0
8
0
16
16
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
70
0
0
0
0
0
% W
% Tyr:
0
0
0
0
24
0
8
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _