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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3E
All Species:
25.76
Human Site:
Y401
Identified Species:
47.22
UniProt:
P60228
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P60228
NP_001559.1
445
52221
Y401
G
N
N
A
V
S
P
Y
Q
Q
V
I
E
K
T
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001090244
396
46427
Q353
N
N
A
V
S
P
Y
Q
Q
V
I
E
K
T
K
Dog
Lupus familis
XP_860062
352
41339
Q309
N
N
A
V
S
P
Y
Q
Q
V
I
E
K
T
K
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
XP_002727410
445
52210
Y401
G
N
N
A
V
S
P
Y
Q
Q
V
I
E
K
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505745
451
52629
Y407
G
N
N
A
V
S
P
Y
Q
Q
V
I
E
K
T
Chicken
Gallus gallus
Q5ZLA5
445
52117
Y401
G
N
N
A
V
S
P
Y
Q
Q
V
I
E
K
T
Frog
Xenopus laevis
Q3B8M3
446
52223
Y402
G
N
N
A
V
S
P
Y
Q
Q
V
I
E
K
T
Zebra Danio
Brachydanio rerio
Q1LUA8
446
52584
Y402
G
N
N
A
V
S
P
Y
Q
Q
V
I
E
K
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O77410
435
51144
P391
H
V
V
M
G
T
Q
P
L
S
P
Y
Q
Q
L
Honey Bee
Apis mellifera
XP_623637
451
52726
Y399
G
G
Q
P
A
S
P
Y
Q
Q
L
V
E
K
I
Nematode Worm
Caenorhab. elegans
O61820
432
50701
L387
G
A
K
I
D
S
K
L
G
Q
V
V
M
G
V
Sea Urchin
Strong. purpuratus
XP_001193661
398
46711
E355
S
P
Y
Q
Q
V
I
E
K
T
K
N
L
I
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7S519
443
51032
D400
L
I
R
D
T
R
L
D
A
K
I
D
Y
K
E
Conservation
Percent
Protein Identity:
100
N.A.
88.9
79
N.A.
N.A.
99
N.A.
92.9
97.5
95.7
93.7
N.A.
59
58.9
49.4
63.3
Protein Similarity:
100
N.A.
88.9
79
N.A.
N.A.
99
N.A.
93.7
99.5
98.4
98.2
N.A.
76.1
76.2
69.4
73.7
P-Site Identity:
100
N.A.
13.3
13.3
N.A.
N.A.
100
N.A.
100
100
100
100
N.A.
0
53.3
26.6
0
P-Site Similarity:
100
N.A.
26.6
26.6
N.A.
N.A.
100
N.A.
100
100
100
100
N.A.
20
66.6
33.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
41.8
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
63.3
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
16
47
8
0
0
0
8
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
8
0
0
8
0
0
0
8
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
8
0
0
0
16
54
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
62
8
0
0
8
0
0
0
8
0
0
0
0
8
0
% G
% His:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
8
0
8
0
0
8
0
0
0
24
47
0
8
8
% I
% Lys:
0
0
8
0
0
0
8
0
8
8
8
0
16
62
16
% K
% Leu:
8
0
0
0
0
0
8
8
8
0
8
0
8
0
8
% L
% Met:
0
0
0
8
0
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
16
62
47
0
0
0
0
0
0
0
0
8
0
0
0
% N
% Pro:
0
8
0
8
0
16
54
8
0
0
8
0
0
0
0
% P
% Gln:
0
0
8
8
8
0
8
16
70
62
0
0
8
8
0
% Q
% Arg:
0
0
8
0
0
8
0
0
0
0
0
0
0
0
0
% R
% Ser:
8
0
0
0
16
62
0
0
0
8
0
0
0
0
0
% S
% Thr:
0
0
0
0
8
8
0
0
0
8
0
0
0
16
47
% T
% Val:
0
8
8
16
47
8
0
0
0
16
54
16
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
16
54
0
0
0
8
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _