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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3E
All Species:
13.64
Human Site:
Y62
Identified Species:
25
UniProt:
P60228
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P60228
NP_001559.1
445
52221
Y62
M
D
V
Y
K
N
L
Y
S
D
D
I
P
H
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001090244
396
46427
E47
E
P
I
V
K
M
F
E
D
P
E
T
T
R
Q
Dog
Lupus familis
XP_860062
352
41339
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
XP_002727410
445
52210
Y62
M
D
V
Y
K
N
L
Y
S
D
D
I
P
H
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505745
451
52629
Y68
M
D
V
Y
K
N
L
Y
S
D
D
I
P
H
A
Chicken
Gallus gallus
Q5ZLA5
445
52117
Y62
M
D
V
Y
K
N
L
Y
S
D
E
I
P
H
A
Frog
Xenopus laevis
Q3B8M3
446
52223
A63
D
V
Y
K
N
L
Y
A
D
K
E
I
P
L
A
Zebra Danio
Brachydanio rerio
Q1LUA8
446
52584
P63
D
V
Y
K
N
L
Y
P
D
K
E
I
P
H
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O77410
435
51144
R60
Y
T
M
D
T
R
K
R
L
N
L
S
Q
E
M
Honey Bee
Apis mellifera
XP_623637
451
52726
P63
D
I
R
K
Q
L
Y
P
N
L
E
V
P
E
E
Nematode Worm
Caenorhab. elegans
O61820
432
50701
P62
I
E
T
Y
N
G
K
P
I
P
A
A
I
E
A
Sea Urchin
Strong. purpuratus
XP_001193661
398
46711
A49
I
I
K
I
F
E
N
A
D
V
R
E
H
I
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7S519
443
51032
E78
Y
V
A
N
L
Y
C
E
L
E
G
L
K
E
P
Conservation
Percent
Protein Identity:
100
N.A.
88.9
79
N.A.
N.A.
99
N.A.
92.9
97.5
95.7
93.7
N.A.
59
58.9
49.4
63.3
Protein Similarity:
100
N.A.
88.9
79
N.A.
N.A.
99
N.A.
93.7
99.5
98.4
98.2
N.A.
76.1
76.2
69.4
73.7
P-Site Identity:
100
N.A.
6.6
0
N.A.
N.A.
100
N.A.
100
93.3
20
20
N.A.
0
6.6
13.3
0
P-Site Similarity:
100
N.A.
20
0
N.A.
N.A.
100
N.A.
100
100
26.6
33.3
N.A.
13.3
33.3
26.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
41.8
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
63.3
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
16
0
0
8
8
0
0
47
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
24
31
0
8
0
0
0
0
31
31
24
0
0
0
0
% D
% Glu:
8
8
0
0
0
8
0
16
0
8
39
8
0
31
8
% E
% Phe:
0
0
0
0
8
0
8
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
8
0
0
0
0
8
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
8
39
0
% H
% Ile:
16
16
8
8
0
0
0
0
8
0
0
47
8
8
0
% I
% Lys:
0
0
8
24
39
0
16
0
0
16
0
0
8
0
0
% K
% Leu:
0
0
0
0
8
24
31
0
16
8
8
8
0
8
0
% L
% Met:
31
0
8
0
0
8
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
8
24
31
8
0
8
8
0
0
0
0
0
% N
% Pro:
0
8
0
0
0
0
0
24
0
16
0
0
54
0
8
% P
% Gln:
0
0
0
0
8
0
0
0
0
0
0
0
8
0
16
% Q
% Arg:
0
0
8
0
0
8
0
8
0
0
8
0
0
8
0
% R
% Ser:
0
0
0
0
0
0
0
0
31
0
0
8
0
0
8
% S
% Thr:
0
8
8
0
8
0
0
0
0
0
0
8
8
0
0
% T
% Val:
0
24
31
8
0
0
0
0
0
8
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
16
0
16
39
0
8
24
31
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _