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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTEN
All Species:
21.52
Human Site:
Y177
Identified Species:
59.17
UniProt:
P60484
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P60484
NP_000305.3
403
47166
Y177
S
Q
R
R
Y
V
Y
Y
Y
S
Y
L
L
K
N
Chimpanzee
Pan troglodytes
XP_521544
462
52650
D233
L
D
Q
W
L
S
E
D
D
N
H
V
A
A
I
Rhesus Macaque
Macaca mulatta
XP_001102446
270
31559
F67
L
L
F
H
K
M
M
F
E
T
I
P
M
F
S
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O08586
403
47134
Y177
S
Q
R
R
Y
V
Y
Y
Y
S
Y
L
L
K
N
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506371
391
45262
Y177
N
T
N
K
Y
Q
H
Y
Y
S
K
R
W
W
G
Chicken
Gallus gallus
Frog
Xenopus laevis
Q9PUT6
402
46859
Y176
S
Q
R
R
Y
V
Y
Y
Y
S
Y
L
L
K
N
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_599147
509
58413
Y185
S
Q
R
R
Y
V
Q
Y
F
S
K
L
V
C
S
Honey Bee
Apis mellifera
NP_001155985
501
56758
Y186
S
Q
R
R
Y
V
D
Y
Y
A
T
L
V
Q
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001177499
393
45424
Y170
S
Q
R
R
Y
V
E
Y
Y
G
N
L
I
V
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74.4
67
N.A.
N.A.
99.7
N.A.
N.A.
77.4
N.A.
88.5
N.A.
N.A.
34.1
40.7
N.A.
54
Protein Similarity:
100
74.4
67
N.A.
N.A.
100
N.A.
N.A.
83.6
N.A.
93.8
N.A.
N.A.
50
56.8
N.A.
68.2
P-Site Identity:
100
0
0
N.A.
N.A.
100
N.A.
N.A.
26.6
N.A.
100
N.A.
N.A.
60
60
N.A.
60
P-Site Similarity:
100
26.6
33.3
N.A.
N.A.
100
N.A.
N.A.
46.6
N.A.
100
N.A.
N.A.
80
80
N.A.
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
12
0
0
12
12
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% C
% Asp:
0
12
0
0
0
0
12
12
12
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
23
0
12
0
0
0
0
0
12
% E
% Phe:
0
0
12
0
0
0
0
12
12
0
0
0
0
12
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
12
% G
% His:
0
0
0
12
0
0
12
0
0
0
12
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
12
0
12
0
12
% I
% Lys:
0
0
0
12
12
0
0
0
0
0
23
0
0
34
0
% K
% Leu:
23
12
0
0
12
0
0
0
0
0
0
67
34
0
0
% L
% Met:
0
0
0
0
0
12
12
0
0
0
0
0
12
0
0
% M
% Asn:
12
0
12
0
0
0
0
0
0
12
12
0
0
0
34
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% P
% Gln:
0
67
12
0
0
12
12
0
0
0
0
0
0
12
0
% Q
% Arg:
0
0
67
67
0
0
0
0
0
0
0
12
0
0
12
% R
% Ser:
67
0
0
0
0
12
0
0
0
56
0
0
0
0
23
% S
% Thr:
0
12
0
0
0
0
0
0
0
12
12
0
0
0
0
% T
% Val:
0
0
0
0
0
67
0
0
0
0
0
12
23
12
0
% V
% Trp:
0
0
0
12
0
0
0
0
0
0
0
0
12
12
0
% W
% Tyr:
0
0
0
0
78
0
34
78
67
0
34
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _