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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF4A1 All Species: 19.97
Human Site: S4 Identified Species: 27.46
UniProt: P60842 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P60842 NP_001407.1 406 46154 S4 _ _ _ _ M S A S Q D S R S R D
Chimpanzee Pan troglodytes A5A6N4 406 46165 S4 _ _ _ _ M S A S Q D S R S R D
Rhesus Macaque Macaca mulatta XP_001085678 406 46086 S4 _ _ _ _ M S A S Q D S R S R D
Dog Lupus familis XP_851852 406 46122 S4 _ _ _ _ M S A S Q D S R T E D
Cat Felis silvestris
Mouse Mus musculus P10630 407 46384 G4 _ _ _ _ M S G G S A D Y N R E
Rat Rattus norvegicus NP_001008336 407 46384 G4 _ _ _ _ M S G G S A D Y N R E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511956 373 42398
Chicken Gallus gallus Q8JFP1 407 46353 G4 _ _ _ _ M S G G S A D Y S R D
Frog Xenopus laevis NP_001086413 406 46058 S4 _ _ _ _ M S A S Y E S R P R D
Zebra Danio Brachydanio rerio NP_938180 406 46235 E4 _ _ _ _ M S S E H E D R P R D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q02748 403 45860 N5 _ _ _ M D D R N E I P Q D G P
Honey Bee Apis mellifera XP_623285 423 48137 S22 G D S K N G P S E S D Q Q T Y
Nematode Worm Caenorhab. elegans P27639 402 45389 V4 _ _ _ _ M T D V K N D V N V S
Sea Urchin Strong. purpuratus NP_001091916 426 48260 S11 I D D E Q A N S Q V T K P G P
Poplar Tree Populus trichocarpa
Maize Zea mays Q41741 410 46518 P6 _ _ M A G L A P E G S Q F D D
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P41376 412 46686 P6 _ _ M A G S A P E G T Q F D A
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7RV88 397 44826 D4 _ _ _ _ M A T D K G L E D I P
Conservation
Percent
Protein Identity: 100 99.7 99.2 99.5 N.A. 89.6 89.6 N.A. 83.9 90.6 95.3 89.6 N.A. 72.4 76.5 68.9 74.6
Protein Similarity: 100 99.7 99.7 99.7 N.A. 96.3 96.3 N.A. 86.2 96.3 99 96.8 N.A. 86.6 87.7 82.7 83.1
P-Site Identity: 100 100 100 81.8 N.A. 27.2 27.2 N.A. 0 45.4 72.7 45.4 N.A. 0 6.6 9 13.3
P-Site Similarity: 100 100 100 90.9 N.A. 45.4 45.4 N.A. 0 45.4 81.8 63.6 N.A. 25 26.6 45.4 40
Percent
Protein Identity: N.A. 68 N.A. 68.2 N.A. 75.8
Protein Similarity: N.A. 81.4 N.A. 81 N.A. 87.1
P-Site Identity: N.A. 23 N.A. 15.3 N.A. 9
P-Site Similarity: N.A. 38.4 N.A. 38.4 N.A. 27.2
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 12 0 12 42 0 0 18 0 0 0 0 6 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 12 6 0 6 6 6 6 0 24 36 0 12 12 48 % D
% Glu: 0 0 0 6 0 0 0 6 24 12 0 6 0 6 12 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 12 0 0 % F
% Gly: 6 0 0 0 12 6 18 18 0 18 0 0 0 12 0 % G
% His: 0 0 0 0 0 0 0 0 6 0 0 0 0 0 0 % H
% Ile: 6 0 0 0 0 0 0 0 0 6 0 0 0 6 0 % I
% Lys: 0 0 0 6 0 0 0 0 12 0 0 6 0 0 0 % K
% Leu: 0 0 0 0 0 6 0 0 0 0 6 0 0 0 0 % L
% Met: 0 0 12 6 65 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 6 0 6 6 0 6 0 0 18 0 0 % N
% Pro: 0 0 0 0 0 0 6 12 0 0 6 0 18 0 18 % P
% Gln: 0 0 0 0 6 0 0 0 30 0 0 24 6 0 0 % Q
% Arg: 0 0 0 0 0 0 6 0 0 0 0 36 0 48 0 % R
% Ser: 0 0 6 0 0 59 6 42 18 6 36 0 24 0 6 % S
% Thr: 0 0 0 0 0 6 6 0 0 0 12 0 6 6 0 % T
% Val: 0 0 0 0 0 0 0 6 0 6 0 6 0 6 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 6 0 0 18 0 0 6 % Y
% Spaces: 83 83 71 65 0 0 0 0 0 0 0 0 0 0 0 % _