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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4A1
All Species:
18.18
Human Site:
S40
Identified Species:
25
UniProt:
P60842
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P60842
NP_001407.1
406
46154
S40
S
F
D
D
M
N
L
S
E
S
L
L
R
G
I
Chimpanzee
Pan troglodytes
A5A6N4
406
46165
S40
S
F
D
D
M
N
L
S
E
S
L
L
R
G
I
Rhesus Macaque
Macaca mulatta
XP_001085678
406
46086
S40
S
F
D
D
M
N
L
S
E
S
L
L
R
G
I
Dog
Lupus familis
XP_851852
406
46122
S40
S
F
D
D
M
N
L
S
E
S
L
L
R
G
I
Cat
Felis silvestris
Mouse
Mus musculus
P10630
407
46384
K41
N
F
D
D
M
N
L
K
E
S
L
L
R
G
I
Rat
Rattus norvegicus
NP_001008336
407
46384
K41
N
F
D
D
M
N
L
K
E
S
L
L
R
G
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511956
373
42398
A33
S
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
Chicken
Gallus gallus
Q8JFP1
407
46353
K41
N
F
D
D
M
N
L
K
E
S
L
L
R
G
I
Frog
Xenopus laevis
NP_001086413
406
46058
S40
S
F
D
D
M
S
L
S
E
S
L
L
R
G
I
Zebra Danio
Brachydanio rerio
NP_938180
406
46235
R40
S
F
D
D
M
N
L
R
E
A
L
L
R
G
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q02748
403
45860
E40
D
D
M
N
L
R
E
E
L
L
R
G
I
Y
G
Honey Bee
Apis mellifera
XP_623285
423
48137
K58
N
F
D
E
M
N
L
K
E
E
L
L
R
G
I
Nematode Worm
Caenorhab. elegans
P27639
402
45389
E39
D
D
M
E
L
K
E
E
L
L
R
G
I
Y
G
Sea Urchin
Strong. purpuratus
NP_001091916
426
48260
R61
N
F
D
D
M
G
L
R
E
S
L
L
R
G
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q41741
410
46518
Q45
S
F
D
S
M
G
L
Q
E
N
L
L
R
G
I
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P41376
412
46686
Q47
S
F
D
A
M
G
L
Q
E
N
L
L
R
G
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7RV88
397
44826
I39
K
P
E
L
L
R
G
I
Y
A
Y
G
F
E
R
Conservation
Percent
Protein Identity:
100
99.7
99.2
99.5
N.A.
89.6
89.6
N.A.
83.9
90.6
95.3
89.6
N.A.
72.4
76.5
68.9
74.6
Protein Similarity:
100
99.7
99.7
99.7
N.A.
96.3
96.3
N.A.
86.2
96.3
99
96.8
N.A.
86.6
87.7
82.7
83.1
P-Site Identity:
100
100
100
100
N.A.
86.6
86.6
N.A.
6.6
86.6
93.3
86.6
N.A.
0
73.3
0
80
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
20
93.3
100
93.3
N.A.
13.3
86.6
13.3
86.6
Percent
Protein Identity:
N.A.
68
N.A.
68.2
N.A.
75.8
Protein Similarity:
N.A.
81.4
N.A.
81
N.A.
87.1
P-Site Identity:
N.A.
73.3
N.A.
73.3
N.A.
0
P-Site Similarity:
N.A.
80
N.A.
80
N.A.
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
6
0
0
0
6
0
12
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
12
12
77
59
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
6
12
0
0
12
12
77
6
0
6
0
6
0
% E
% Phe:
0
77
0
0
0
0
0
0
0
0
6
0
6
0
0
% F
% Gly:
0
0
0
0
6
18
6
0
0
6
0
18
0
77
12
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
6
0
6
0
0
0
0
12
0
77
% I
% Lys:
6
0
0
0
0
6
0
24
0
0
0
0
6
0
0
% K
% Leu:
0
6
6
6
18
0
77
0
12
12
77
77
0
0
0
% L
% Met:
0
0
12
0
77
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
30
0
0
6
0
53
0
0
0
12
0
0
0
0
0
% N
% Pro:
0
6
0
0
0
0
0
0
0
0
0
0
0
6
0
% P
% Gln:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
6
0
12
0
12
0
0
12
0
77
0
6
% R
% Ser:
53
0
0
6
0
6
0
30
0
53
0
0
0
0
6
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
6
0
12
0
6
0
0
12
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _