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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4A1
All Species:
21.75
Human Site:
S7
Identified Species:
29.91
UniProt:
P60842
Number Species:
16
Phosphosite Substitution
Charge Score:
0.38
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P60842
NP_001407.1
406
46154
S7
_
M
S
A
S
Q
D
S
R
S
R
D
N
G
P
Chimpanzee
Pan troglodytes
A5A6N4
406
46165
S7
_
M
S
A
S
Q
D
S
R
S
R
D
N
G
P
Rhesus Macaque
Macaca mulatta
XP_001085678
406
46086
S7
_
M
S
A
S
Q
D
S
R
S
R
D
N
G
P
Dog
Lupus familis
XP_851852
406
46122
S7
_
M
S
A
S
Q
D
S
R
T
E
D
N
G
P
Cat
Felis silvestris
Mouse
Mus musculus
P10630
407
46384
D7
_
M
S
G
G
S
A
D
Y
N
R
E
H
G
G
Rat
Rattus norvegicus
NP_001008336
407
46384
D7
_
M
S
G
G
S
A
D
Y
N
R
E
H
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511956
373
42398
Chicken
Gallus gallus
Q8JFP1
407
46353
D7
_
M
S
G
G
S
A
D
Y
S
R
D
H
G
G
Frog
Xenopus laevis
NP_001086413
406
46058
S7
_
M
S
A
S
Y
E
S
R
P
R
D
N
G
P
Zebra Danio
Brachydanio rerio
NP_938180
406
46235
D7
_
M
S
S
E
H
E
D
R
P
R
D
N
G
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q02748
403
45860
P8
M
D
D
R
N
E
I
P
Q
D
G
P
A
S
M
Honey Bee
Apis mellifera
XP_623285
423
48137
D25
K
N
G
P
S
E
S
D
Q
Q
T
Y
D
G
P
Nematode Worm
Caenorhab. elegans
P27639
402
45389
D7
_
M
T
D
V
K
N
D
V
N
V
S
S
V
V
Sea Urchin
Strong. purpuratus
NP_001091916
426
48260
T14
E
Q
A
N
S
Q
V
T
K
P
G
P
G
P
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q41741
410
46518
S9
A
G
L
A
P
E
G
S
Q
F
D
D
K
Q
Y
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P41376
412
46686
T9
A
G
S
A
P
E
G
T
Q
F
D
A
R
Q
F
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7RV88
397
44826
L7
_
M
A
T
D
K
G
L
E
D
I
P
E
G
Q
Conservation
Percent
Protein Identity:
100
99.7
99.2
99.5
N.A.
89.6
89.6
N.A.
83.9
90.6
95.3
89.6
N.A.
72.4
76.5
68.9
74.6
Protein Similarity:
100
99.7
99.7
99.7
N.A.
96.3
96.3
N.A.
86.2
96.3
99
96.8
N.A.
86.6
87.7
82.7
83.1
P-Site Identity:
100
100
100
85.7
N.A.
28.5
28.5
N.A.
0
42.8
78.5
57.1
N.A.
0
20
7.1
13.3
P-Site Similarity:
100
100
100
92.8
N.A.
50
50
N.A.
0
50
85.7
71.4
N.A.
20
40
42.8
33.3
Percent
Protein Identity:
N.A.
68
N.A.
68.2
N.A.
75.8
Protein Similarity:
N.A.
81.4
N.A.
81
N.A.
87.1
P-Site Identity:
N.A.
20
N.A.
13.3
N.A.
14.2
P-Site Similarity:
N.A.
33.3
N.A.
33.3
N.A.
28.5
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
0
12
42
0
0
18
0
0
0
0
6
6
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
6
6
6
6
0
24
36
0
12
12
48
6
0
0
% D
% Glu:
6
0
0
0
6
24
12
0
6
0
6
12
6
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
6
% F
% Gly:
0
12
6
18
18
0
18
0
0
0
12
0
6
65
24
% G
% His:
0
0
0
0
0
6
0
0
0
0
0
0
18
0
0
% H
% Ile:
0
0
0
0
0
0
6
0
0
0
6
0
0
0
0
% I
% Lys:
6
0
0
0
0
12
0
0
6
0
0
0
6
0
0
% K
% Leu:
0
0
6
0
0
0
0
6
0
0
0
0
0
0
0
% L
% Met:
6
65
0
0
0
0
0
0
0
0
0
0
0
0
6
% M
% Asn:
0
6
0
6
6
0
6
0
0
18
0
0
36
0
0
% N
% Pro:
0
0
0
6
12
0
0
6
0
18
0
18
0
6
42
% P
% Gln:
0
6
0
0
0
30
0
0
24
6
0
0
0
12
6
% Q
% Arg:
0
0
0
6
0
0
0
0
36
0
48
0
6
0
0
% R
% Ser:
0
0
59
6
42
18
6
36
0
24
0
6
6
6
0
% S
% Thr:
0
0
6
6
0
0
0
12
0
6
6
0
0
0
0
% T
% Val:
0
0
0
0
6
0
6
0
6
0
6
0
0
6
6
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
6
0
0
18
0
0
6
0
0
6
% Y
% Spaces:
65
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _