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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4A1
All Species:
59.09
Human Site:
T289
Identified Species:
81.25
UniProt:
P60842
Number Species:
16
Phosphosite Substitution
Charge Score:
0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P60842
NP_001407.1
406
46154
T289
R
R
K
V
D
W
L
T
E
K
M
H
A
R
D
Chimpanzee
Pan troglodytes
A5A6N4
406
46165
T289
R
R
K
V
D
W
L
T
E
K
M
H
A
R
D
Rhesus Macaque
Macaca mulatta
XP_001085678
406
46086
T289
Q
R
K
V
D
W
L
T
E
K
M
H
A
R
D
Dog
Lupus familis
XP_851852
406
46122
T289
R
R
K
V
D
W
L
T
E
K
M
H
A
R
D
Cat
Felis silvestris
Mouse
Mus musculus
P10630
407
46384
T290
R
R
K
V
D
W
L
T
E
K
M
H
A
R
D
Rat
Rattus norvegicus
NP_001008336
407
46384
T290
R
R
K
V
D
W
L
T
E
K
M
H
A
R
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511956
373
42398
D272
T
V
S
A
M
H
G
D
M
D
Q
K
E
R
D
Chicken
Gallus gallus
Q8JFP1
407
46353
T290
R
R
K
V
D
W
L
T
E
K
M
H
A
R
D
Frog
Xenopus laevis
NP_001086413
406
46058
T289
R
R
K
V
D
W
L
T
E
K
M
H
A
R
D
Zebra Danio
Brachydanio rerio
NP_938180
406
46235
T289
R
R
K
V
D
W
L
T
E
K
M
H
A
R
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q02748
403
45860
T286
R
R
K
V
D
Q
L
T
Q
E
M
S
I
H
N
Honey Bee
Apis mellifera
XP_623285
423
48137
T306
R
R
K
V
D
W
L
T
E
S
M
R
T
R
D
Nematode Worm
Caenorhab. elegans
P27639
402
45389
T285
R
R
K
V
D
T
L
T
E
K
M
T
E
N
Q
Sea Urchin
Strong. purpuratus
NP_001091916
426
48260
C309
R
R
K
V
D
W
L
C
Q
K
M
H
E
R
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q41741
410
46518
T293
R
R
K
V
D
W
L
T
D
K
M
R
S
R
D
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P41376
412
46686
T295
R
R
K
V
D
W
L
T
D
K
M
R
S
R
D
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7RV88
397
44826
T280
R
R
K
V
D
W
L
T
D
K
L
T
A
R
D
Conservation
Percent
Protein Identity:
100
99.7
99.2
99.5
N.A.
89.6
89.6
N.A.
83.9
90.6
95.3
89.6
N.A.
72.4
76.5
68.9
74.6
Protein Similarity:
100
99.7
99.7
99.7
N.A.
96.3
96.3
N.A.
86.2
96.3
99
96.8
N.A.
86.6
87.7
82.7
83.1
P-Site Identity:
100
100
93.3
100
N.A.
100
100
N.A.
13.3
100
100
100
N.A.
53.3
80
66.6
80
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
13.3
100
100
100
N.A.
73.3
80
66.6
86.6
Percent
Protein Identity:
N.A.
68
N.A.
68.2
N.A.
75.8
Protein Similarity:
N.A.
81.4
N.A.
81
N.A.
87.1
P-Site Identity:
N.A.
80
N.A.
80
N.A.
80
P-Site Similarity:
N.A.
93.3
N.A.
93.3
N.A.
93.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
6
0
0
0
0
0
0
0
0
59
0
0
% A
% Cys:
0
0
0
0
0
0
0
6
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
95
0
0
6
18
6
0
0
0
0
89
% D
% Glu:
0
0
0
0
0
0
0
0
65
6
0
0
18
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
6
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
6
0
0
0
0
0
59
0
6
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
6
0
0
% I
% Lys:
0
0
95
0
0
0
0
0
0
83
0
6
0
0
0
% K
% Leu:
0
0
0
0
0
0
95
0
0
0
6
0
0
0
0
% L
% Met:
0
0
0
0
6
0
0
0
6
0
89
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
6
6
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
6
0
0
0
0
6
0
0
12
0
6
0
0
0
6
% Q
% Arg:
89
95
0
0
0
0
0
0
0
0
0
18
0
89
0
% R
% Ser:
0
0
6
0
0
0
0
0
0
6
0
6
12
0
0
% S
% Thr:
6
0
0
0
0
6
0
89
0
0
0
12
6
0
0
% T
% Val:
0
6
0
95
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
83
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _