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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4A1
All Species:
51.52
Human Site:
Y197
Identified Species:
70.83
UniProt:
P60842
Number Species:
16
Phosphosite Substitution
Charge Score:
0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P60842
NP_001407.1
406
46154
Y197
R
G
F
K
D
Q
I
Y
D
I
F
Q
K
L
N
Chimpanzee
Pan troglodytes
A5A6N4
406
46165
Y197
R
G
F
K
D
Q
I
Y
D
I
F
Q
K
L
N
Rhesus Macaque
Macaca mulatta
XP_001085678
406
46086
Y197
R
G
F
K
D
Q
I
Y
D
I
F
Q
K
L
N
Dog
Lupus familis
XP_851852
406
46122
Y197
R
G
F
K
D
Q
I
Y
D
I
F
Q
K
L
N
Cat
Felis silvestris
Mouse
Mus musculus
P10630
407
46384
Y198
R
G
F
K
D
Q
I
Y
E
I
F
Q
K
L
N
Rat
Rattus norvegicus
NP_001008336
407
46384
Y198
R
G
F
K
D
Q
I
Y
E
I
F
Q
K
L
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511956
373
42398
M183
V
V
L
L
S
A
T
M
P
S
D
V
L
E
V
Chicken
Gallus gallus
Q8JFP1
407
46353
Y198
R
G
F
K
D
Q
I
Y
E
I
F
Q
K
L
S
Frog
Xenopus laevis
NP_001086413
406
46058
Y197
R
G
F
K
D
Q
I
Y
D
I
F
Q
K
L
S
Zebra Danio
Brachydanio rerio
NP_938180
406
46235
Y197
R
G
F
K
D
Q
I
Y
E
I
F
Q
K
L
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q02748
403
45860
Q194
R
G
F
K
D
Q
I
Q
D
V
F
K
M
L
P
Honey Bee
Apis mellifera
XP_623285
423
48137
H214
R
G
F
K
D
Q
I
H
D
V
F
K
L
L
P
Nematode Worm
Caenorhab. elegans
P27639
402
45389
Y193
R
G
F
K
D
Q
I
Y
E
V
F
R
S
M
P
Sea Urchin
Strong. purpuratus
NP_001091916
426
48260
Y217
R
G
F
K
D
Q
I
Y
D
V
F
S
W
L
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q41741
410
46518
Y201
R
G
F
K
D
Q
I
Y
D
I
F
Q
L
L
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P41376
412
46686
Y203
R
G
F
K
D
Q
I
Y
D
I
F
Q
L
L
P
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7RV88
397
44826
D189
G
F
T
E
Q
I
Y
D
I
F
Q
L
L
P
Q
Conservation
Percent
Protein Identity:
100
99.7
99.2
99.5
N.A.
89.6
89.6
N.A.
83.9
90.6
95.3
89.6
N.A.
72.4
76.5
68.9
74.6
Protein Similarity:
100
99.7
99.7
99.7
N.A.
96.3
96.3
N.A.
86.2
96.3
99
96.8
N.A.
86.6
87.7
82.7
83.1
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
0
86.6
93.3
86.6
N.A.
66.6
66.6
60
73.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
0
100
100
93.3
N.A.
80
86.6
86.6
80
Percent
Protein Identity:
N.A.
68
N.A.
68.2
N.A.
75.8
Protein Similarity:
N.A.
81.4
N.A.
81
N.A.
87.1
P-Site Identity:
N.A.
86.6
N.A.
86.6
N.A.
0
P-Site Similarity:
N.A.
86.6
N.A.
86.6
N.A.
6.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
6
0
0
0
0
0
0
0
0
6
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
89
0
0
6
59
0
6
0
0
0
0
% D
% Glu:
0
0
0
6
0
0
0
0
30
0
0
0
0
6
0
% E
% Phe:
0
6
89
0
0
0
0
0
0
6
89
0
0
0
0
% F
% Gly:
6
89
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
6
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
6
89
0
6
65
0
0
0
0
0
% I
% Lys:
0
0
0
89
0
0
0
0
0
0
0
12
53
0
0
% K
% Leu:
0
0
6
6
0
0
0
0
0
0
0
6
30
83
0
% L
% Met:
0
0
0
0
0
0
0
6
0
0
0
0
6
6
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
36
% N
% Pro:
0
0
0
0
0
0
0
0
6
0
0
0
0
6
36
% P
% Gln:
0
0
0
0
6
89
0
6
0
0
6
65
0
0
6
% Q
% Arg:
89
0
0
0
0
0
0
0
0
0
0
6
0
0
0
% R
% Ser:
0
0
0
0
6
0
0
0
0
6
0
6
6
0
12
% S
% Thr:
0
0
6
0
0
0
6
0
0
0
0
0
0
0
0
% T
% Val:
6
6
0
0
0
0
0
0
0
24
0
6
0
0
6
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
6
0
0
% W
% Tyr:
0
0
0
0
0
0
6
77
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _