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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4A1
All Species:
54.85
Human Site:
Y48
Identified Species:
75.42
UniProt:
P60842
Number Species:
16
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P60842
NP_001407.1
406
46154
Y48
E
S
L
L
R
G
I
Y
A
Y
G
F
E
K
P
Chimpanzee
Pan troglodytes
A5A6N4
406
46165
Y48
E
S
L
L
R
G
I
Y
A
Y
G
F
E
K
P
Rhesus Macaque
Macaca mulatta
XP_001085678
406
46086
Y48
E
S
L
L
R
G
I
Y
A
Y
G
F
E
K
P
Dog
Lupus familis
XP_851852
406
46122
Y48
E
S
L
L
R
G
I
Y
A
Y
G
F
E
K
P
Cat
Felis silvestris
Mouse
Mus musculus
P10630
407
46384
Y49
E
S
L
L
R
G
I
Y
A
Y
G
F
E
K
P
Rat
Rattus norvegicus
NP_001008336
407
46384
Y49
E
S
L
L
R
G
I
Y
A
Y
G
F
E
K
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511956
373
42398
A41
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
L
Chicken
Gallus gallus
Q8JFP1
407
46353
Y49
E
S
L
L
R
G
I
Y
A
Y
G
F
E
K
P
Frog
Xenopus laevis
NP_001086413
406
46058
Y48
E
S
L
L
R
G
I
Y
A
Y
G
F
E
K
P
Zebra Danio
Brachydanio rerio
NP_938180
406
46235
Y48
E
A
L
L
R
G
I
Y
A
Y
G
F
E
K
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q02748
403
45860
Y48
L
L
R
G
I
Y
G
Y
G
F
E
K
P
S
A
Honey Bee
Apis mellifera
XP_623285
423
48137
Y66
E
E
L
L
R
G
I
Y
A
Y
G
F
E
K
P
Nematode Worm
Caenorhab. elegans
P27639
402
45389
F47
L
L
R
G
I
Y
G
F
G
F
E
K
P
S
A
Sea Urchin
Strong. purpuratus
NP_001091916
426
48260
Y69
E
S
L
L
R
G
I
Y
A
Y
G
F
E
K
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q41741
410
46518
Y53
E
N
L
L
R
G
I
Y
A
Y
G
F
E
K
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P41376
412
46686
Y55
E
N
L
L
R
G
I
Y
A
Y
G
F
E
K
P
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7RV88
397
44826
P47
Y
A
Y
G
F
E
R
P
S
A
I
Q
Q
R
A
Conservation
Percent
Protein Identity:
100
99.7
99.2
99.5
N.A.
89.6
89.6
N.A.
83.9
90.6
95.3
89.6
N.A.
72.4
76.5
68.9
74.6
Protein Similarity:
100
99.7
99.7
99.7
N.A.
96.3
96.3
N.A.
86.2
96.3
99
96.8
N.A.
86.6
87.7
82.7
83.1
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
0
100
100
93.3
N.A.
6.6
93.3
0
100
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
6.6
100
100
100
N.A.
13.3
93.3
13.3
100
Percent
Protein Identity:
N.A.
68
N.A.
68.2
N.A.
75.8
Protein Similarity:
N.A.
81.4
N.A.
81
N.A.
87.1
P-Site Identity:
N.A.
93.3
N.A.
93.3
N.A.
0
P-Site Similarity:
N.A.
100
N.A.
100
N.A.
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
12
0
0
0
0
0
6
77
6
0
0
6
0
18
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
77
6
0
6
0
6
0
0
0
0
12
0
77
0
0
% E
% Phe:
0
0
6
0
6
0
0
6
0
12
0
77
0
0
0
% F
% Gly:
0
6
0
18
0
77
12
0
12
0
77
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
12
0
77
0
6
0
6
0
0
6
0
% I
% Lys:
0
0
0
0
6
0
0
0
0
0
0
12
0
77
0
% K
% Leu:
12
12
77
77
0
0
0
0
0
0
0
0
0
0
6
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
6
0
6
0
0
0
0
12
0
77
% P
% Gln:
0
0
0
0
0
0
0
0
0
6
6
6
6
0
0
% Q
% Arg:
0
0
12
0
77
0
6
0
0
0
0
6
0
6
0
% R
% Ser:
0
53
0
0
0
0
6
0
6
0
0
0
0
12
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
12
0
6
0
0
12
0
83
0
77
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _