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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SNAP25 All Species: 48.18
Human Site: S28 Identified Species: 81.54
UniProt: P60880 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P60880 NP_003072.2 206 23315 S28 L A D E S L E S T R R M L Q L
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001105155 211 23235 S23 I T D E S L E S T R R I L G L
Dog Lupus familis XP_859386 207 23459 S28 L A D E S L E S T R R M L Q L
Cat Felis silvestris
Mouse Mus musculus O09044 210 23242 S23 V T D E S L E S T R R I L G L
Rat Rattus norvegicus P60881 206 23297 S28 L A D E S L E S T R R M L Q L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507841 243 26184 S24 V T D E S L E S T R R M L Q L
Chicken Gallus gallus XP_421159 209 23585 S23 V T D E S L E S T R R I L G L
Frog Xenopus laevis NP_001080510 206 23168 S28 L A D E S L E S T R R M L Q Y
Zebra Danio Brachydanio rerio Q5TZ66 204 22839 S28 L A D E S L E S T R R M L Q L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P36975 212 23667 S35 V A D E S L E S T R R M L A L
Honey Bee Apis mellifera XP_394588 213 23546 S36 T T D E S L E S T R R M L A L
Nematode Worm Caenorhab. elegans P83351 277 31097 S53 T L Q E S L D S T E R S R R H
Sea Urchin Strong. purpuratus NP_999754 212 23995 S30 Q T D E S L E S T R R M L Q M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LMG8 263 29057 G80 K A E E T T K G V N N C L K I
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 60.6 94.1 N.A. 61.4 100 N.A. 57.6 59.3 95.1 93.1 N.A. 60.3 60.5 22.3 60.3
Protein Similarity: 100 N.A. 76.3 97 N.A. 77.6 100 N.A. 67.9 76.5 97 96.1 N.A. 75 74.1 38.6 74.5
P-Site Identity: 100 N.A. 73.3 100 N.A. 73.3 100 N.A. 86.6 73.3 93.3 100 N.A. 86.6 80 40 80
P-Site Similarity: 100 N.A. 86.6 100 N.A. 86.6 100 N.A. 93.3 86.6 93.3 100 N.A. 93.3 80 53.3 86.6
Percent
Protein Identity: N.A. N.A. N.A. 23.1 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 42.5 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 20 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 53.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 50 0 0 0 0 0 0 0 0 0 0 0 15 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % C
% Asp: 0 0 86 0 0 0 8 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 8 100 0 0 86 0 0 8 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 8 0 0 0 0 0 22 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % H
% Ile: 8 0 0 0 0 0 0 0 0 0 0 22 0 0 8 % I
% Lys: 8 0 0 0 0 0 8 0 0 0 0 0 0 8 0 % K
% Leu: 36 8 0 0 0 93 0 0 0 0 0 0 93 0 72 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 65 0 0 8 % M
% Asn: 0 0 0 0 0 0 0 0 0 8 8 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 8 0 8 0 0 0 0 0 0 0 0 0 0 50 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 86 93 0 8 8 0 % R
% Ser: 0 0 0 0 93 0 0 93 0 0 0 8 0 0 0 % S
% Thr: 15 43 0 0 8 8 0 0 93 0 0 0 0 0 0 % T
% Val: 29 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _