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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDC42 All Species: 8.79
Human Site: T182 Identified Species: 12.89
UniProt: P60953 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P60953 NP_001034891.1 191 21311 T182 A A L E P P E T Q P K R K C C
Chimpanzee Pan troglodytes XP_001159920 191 21268 P182 A A L E P P E P K K S R R C V
Rhesus Macaque Macaca mulatta XP_001117007 191 21241 P182 A A L E P P E P K K S R R C V
Dog Lupus familis XP_849332 191 21210 P182 A A L E P P E P K K S R R C V
Cat Felis silvestris
Mouse Mus musculus P60766 191 21292 T182 A A L E P P E T Q P K R K C C
Rat Rattus norvegicus Q6RUV5 192 21432 V182 A V L C P P P V K K R K R K C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516353 201 22485 G193 C S A L T Q E G L R E G L L E
Chicken Gallus gallus Q90694 191 21254 P182 A A L E P P E P K K T R R C V
Frog Xenopus laevis NP_001079368 191 21285 P182 A A L E P P E P K K K R K C M
Zebra Danio Brachydanio rerio NP_001018130 191 21351 T182 A A L E P P E T Q R K R K C C
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P40793 191 21384 P182 A A L E P P E P T K K R K C K
Honey Bee Apis mellifera XP_394608 191 21185 P182 A A L E P P E P V K K R K C T
Nematode Worm Caenorhab. elegans Q05062 191 21147 Q182 A A L D P P Q Q E K K K K C N
Sea Urchin Strong. purpuratus XP_789429 191 21304 P182 A A L E P P E P V K K K R C R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q38912 198 21710 N183 V V L Q P P K N K K K K K R K
Baker's Yeast Sacchar. cerevisiae P19073 191 21304 I182 A A L E P P V I K K S K K C A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.7 94.2 94.7 N.A. 100 70.3 N.A. 84 95.2 96.3 99.4 N.A. 91.6 91 86.3 88.4
Protein Similarity: 100 96.8 96.8 96.8 N.A. 100 81.2 N.A. 84.5 97.3 97.9 99.4 N.A. 94.2 95.2 94.7 94.2
P-Site Identity: 100 60 60 60 N.A. 100 33.3 N.A. 6.6 60 73.3 93.3 N.A. 73.3 73.3 53.3 60
P-Site Similarity: 100 73.3 73.3 73.3 N.A. 100 60 N.A. 20 73.3 80 93.3 N.A. 73.3 73.3 80 73.3
Percent
Protein Identity: N.A. N.A. N.A. 54 79.5 N.A.
Protein Similarity: N.A. N.A. N.A. 69.1 87.4 N.A.
P-Site Identity: N.A. N.A. N.A. 33.3 53.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 60 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 88 82 7 0 0 0 0 0 0 0 0 0 0 0 7 % A
% Cys: 7 0 0 7 0 0 0 0 0 0 0 0 0 82 25 % C
% Asp: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 75 0 0 75 0 7 0 7 0 0 0 7 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 7 0 0 0 7 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 7 0 50 75 57 32 57 7 13 % K
% Leu: 0 0 94 7 0 0 0 0 7 0 0 0 7 7 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % M
% Asn: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 7 % N
% Pro: 0 0 0 0 94 94 7 50 0 13 0 0 0 0 0 % P
% Gln: 0 0 0 7 0 7 7 7 19 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 13 7 63 38 7 7 % R
% Ser: 0 7 0 0 0 0 0 0 0 0 25 0 0 0 0 % S
% Thr: 0 0 0 0 7 0 0 19 7 0 7 0 0 0 7 % T
% Val: 7 13 0 0 0 0 7 7 13 0 0 0 0 0 25 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _