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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CXCR4 All Species: 32.12
Human Site: S341 Identified Species: 78.52
UniProt: P61073 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P61073 NP_001008540.1 352 39746 S341 R G G H S S V S T E S E S S S
Chimpanzee Pan troglodytes P61072 352 39727 S341 R G G H S S V S T E S E S S S
Rhesus Macaque Macaca mulatta P79394 352 39721 S341 R G G H S S V S T E S E S S S
Dog Lupus familis XP_541909 367 41880 S354 R E G S V K L S S M L L E T T
Cat Felis silvestris
Mouse Mus musculus P70658 359 40408 S348 R G G H S S V S T E S E S S S
Rat Rattus norvegicus O08565 349 39316 S338 R G G H S S V S T E S E S S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510648 388 43438 S377 R A G H S S V S T E S E S S S
Chicken Gallus gallus NP_989948 358 40076 S347 R G G H S S V S T E S E S S S
Frog Xenopus laevis Q7ZXJ7 358 40009 T348 A G L S S V S T E S E S S S F
Zebra Danio Brachydanio rerio XP_002663363 360 40163 T350 T G M S S V S T E S E S S S F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 100 98.3 34.5 N.A. 89.4 90.6 N.A. 77 81 74.3 66.3 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 100 99.7 53.4 N.A. 94.7 95.1 N.A. 85.3 90.2 85.1 78.8 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 20 N.A. 100 100 N.A. 93.3 100 26.6 26.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 46.6 N.A. 100 100 N.A. 93.3 100 33.3 33.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 10 0 0 0 0 0 0 20 70 20 70 10 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 20 % F
% Gly: 0 80 80 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 70 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 10 0 0 0 10 0 0 0 10 10 0 0 0 % L
% Met: 0 0 10 0 0 0 0 0 0 10 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 80 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 30 90 70 20 80 10 20 70 20 90 90 70 % S
% Thr: 10 0 0 0 0 0 0 20 70 0 0 0 0 10 10 % T
% Val: 0 0 0 0 10 20 70 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _