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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CXCR4
All Species:
19.7
Human Site:
Y21
Identified Species:
48.15
UniProt:
P61073
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P61073
NP_001008540.1
352
39746
Y21
E
E
M
G
S
G
D
Y
D
S
M
K
E
P
C
Chimpanzee
Pan troglodytes
P61072
352
39727
Y21
E
E
M
G
S
G
D
Y
D
S
M
K
E
P
C
Rhesus Macaque
Macaca mulatta
P79394
352
39721
Y21
E
E
M
G
S
G
D
Y
D
S
I
K
E
P
C
Dog
Lupus familis
XP_541909
367
41880
D26
Y
H
S
T
S
P
V
D
D
Y
M
N
F
P
D
Cat
Felis silvestris
Mouse
Mus musculus
P70658
359
40408
Y23
E
E
V
G
S
G
D
Y
D
S
N
K
E
P
C
Rat
Rattus norvegicus
O08565
349
39316
E23
G
D
Y
D
S
N
K
E
P
C
F
R
D
E
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510648
388
43438
Y57
S
G
S
G
S
G
D
Y
D
N
Y
K
E
P
C
Chicken
Gallus gallus
NP_989948
358
40076
Y27
E
E
I
G
S
A
D
Y
G
D
Y
G
E
P
C
Frog
Xenopus laevis
Q7ZXJ7
358
40009
F25
T
E
N
G
S
G
D
F
E
D
F
I
E
P
C
Zebra Danio
Brachydanio rerio
XP_002663363
360
40163
G27
E
F
G
S
G
D
I
G
A
N
F
E
V
P
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
100
98.3
34.5
N.A.
89.4
90.6
N.A.
77
81
74.3
66.3
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
100
99.7
53.4
N.A.
94.7
95.1
N.A.
85.3
90.2
85.1
78.8
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
26.6
N.A.
86.6
6.6
N.A.
66.6
60
53.3
20
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
26.6
N.A.
93.3
26.6
N.A.
73.3
66.6
66.6
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
10
0
0
10
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
80
% C
% Asp:
0
10
0
10
0
10
70
10
60
20
0
0
10
0
10
% D
% Glu:
60
60
0
0
0
0
0
10
10
0
0
10
70
10
0
% E
% Phe:
0
10
0
0
0
0
0
10
0
0
30
0
10
0
0
% F
% Gly:
10
10
10
70
10
60
0
10
10
0
0
10
0
0
0
% G
% His:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
0
0
0
10
0
0
0
10
10
0
0
0
% I
% Lys:
0
0
0
0
0
0
10
0
0
0
0
50
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
30
0
0
0
0
0
0
0
30
0
0
0
0
% M
% Asn:
0
0
10
0
0
10
0
0
0
20
10
10
0
0
10
% N
% Pro:
0
0
0
0
0
10
0
0
10
0
0
0
0
90
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% R
% Ser:
10
0
20
10
90
0
0
0
0
40
0
0
0
0
0
% S
% Thr:
10
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
10
0
0
0
10
0
0
0
0
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
10
0
0
0
0
60
0
10
20
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _