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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ACTR1A All Species: 29.09
Human Site: Y241 Identified Species: 40
UniProt: P61163 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P61163 NP_005727.1 376 42614 Y241 L E T E K A Q Y Y L P D G S T
Chimpanzee Pan troglodytes XP_001155293 376 42274 Y241 L E T E K V Q Y T L P D G S T
Rhesus Macaque Macaca mulatta XP_001101028 376 42275 Y241 L E T E K V Q Y T L P D G S T
Dog Lupus familis XP_854473 376 42271 Y241 L E T E K V Q Y T L P D G S V
Cat Felis silvestris
Mouse Mus musculus Q8R5C5 376 42263 Y241 L E T E K V Q Y T L P D G S T
Rat Rattus norvegicus P68035 377 42000 L238 T A A S S S S L E K S Y E L P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509975 345 38928 V214 S S S E F E I V K T I K E R A
Chicken Gallus gallus P08023 377 41976 L238 T A A S S S S L E K S Y E L P
Frog Xenopus laevis P10995 377 41970 L238 T A A S S S S L E K S Y E L P
Zebra Danio Brachydanio rerio NP_998537 376 42387 Y241 L E T E K A Q Y T L P D G S T
Tiger Blowfish Takifugu rubipres P53480 377 41956 L238 T A A S S S S L E K S Y E L P
Fruit Fly Dros. melanogaster P45889 376 42701 Y241 V E T E K F A Y K L P D G K I
Honey Bee Apis mellifera XP_623834 376 42650 Y241 I E T E K F Q Y I L P D G S Y
Nematode Worm Caenorhab. elegans NP_497108 374 42053 A240 N S V K S S Y A L P D T T K I
Sea Urchin Strong. purpuratus XP_796462 375 42304 Y240 S E A E K T T Y T L P D G S H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P53492 377 41717 V238 T A K S S S S V E K N Y E L P
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa P38673 380 42364 D239 E W A A A K M D P A K I A E Y
Conservation
Percent
Protein Identity: 100 90.1 90.9 90.9 N.A. 91.2 53.3 N.A. 91.4 53 53 93 53.3 79.2 84.5 69.9 88.3
Protein Similarity: 100 97.6 97.6 97.6 N.A. 97.6 74.2 N.A. 91.4 74.2 74.2 98.1 74.2 92 94.1 84.8 94.9
P-Site Identity: 100 86.6 86.6 80 N.A. 86.6 0 N.A. 6.6 0 0 93.3 0 60 73.3 0 60
P-Site Similarity: 100 86.6 86.6 80 N.A. 86.6 6.6 N.A. 13.3 6.6 6.6 93.3 6.6 66.6 80 13.3 60
Percent
Protein Identity: N.A. N.A. N.A. 54.1 N.A. 63.1
Protein Similarity: N.A. N.A. N.A. 75.8 N.A. 81
P-Site Identity: N.A. N.A. N.A. 0 N.A. 0
P-Site Similarity: N.A. N.A. N.A. 6.6 N.A. 0
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 30 36 6 6 12 6 6 0 6 0 0 6 0 6 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 6 0 0 6 53 0 0 0 % D
% Glu: 6 53 0 59 0 6 0 0 30 0 0 0 36 6 0 % E
% Phe: 0 0 0 0 6 12 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 53 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 % H
% Ile: 6 0 0 0 0 0 6 0 6 0 6 6 0 0 12 % I
% Lys: 0 0 6 6 53 6 0 0 12 30 6 6 0 12 0 % K
% Leu: 36 0 0 0 0 0 0 24 6 53 0 0 0 30 0 % L
% Met: 0 0 0 0 0 0 6 0 0 0 0 0 0 0 0 % M
% Asn: 6 0 0 0 0 0 0 0 0 0 6 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 6 6 53 0 0 0 30 % P
% Gln: 0 0 0 0 0 0 42 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 6 0 % R
% Ser: 12 12 6 30 36 36 30 0 0 0 24 0 0 48 0 % S
% Thr: 30 0 48 0 0 6 6 0 36 6 0 6 6 0 30 % T
% Val: 6 0 6 0 0 24 0 12 0 0 0 0 0 0 6 % V
% Trp: 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 6 53 6 0 0 30 0 0 12 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _