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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ISL1
All Species:
32.12
Human Site:
S269
Identified Species:
64.24
UniProt:
P61371
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P61371
NP_002193.2
349
39036
S269
G
T
P
M
V
A
A
S
P
E
R
H
D
G
G
Chimpanzee
Pan troglodytes
Q5IS44
406
44776
G268
L
V
D
R
L
E
P
G
E
L
I
P
N
G
P
Rhesus Macaque
Macaca mulatta
XP_001104982
360
39837
S280
G
T
P
L
V
A
G
S
P
I
R
H
E
N
A
Dog
Lupus familis
XP_853721
346
38714
S266
G
T
P
M
V
A
A
S
P
E
R
H
D
G
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9CXV0
359
39637
S279
G
T
P
L
V
A
G
S
P
I
G
H
E
N
A
Rat
Rattus norvegicus
P61374
349
39017
S269
G
T
P
M
V
A
A
S
P
E
R
H
D
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508080
665
71117
S585
G
T
P
M
V
A
A
S
P
E
R
H
D
G
G
Chicken
Gallus gallus
P50211
349
39015
S269
G
T
P
M
V
A
A
S
P
E
R
H
D
G
G
Frog
Xenopus laevis
P29674
403
44916
G267
L
V
D
R
L
E
P
G
E
L
I
P
N
G
P
Zebra Danio
Brachydanio rerio
P53405
349
39162
S269
G
T
P
M
V
A
T
S
P
E
R
H
D
G
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_476775
534
58026
S330
G
I
P
M
I
A
S
S
P
V
R
H
D
S
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781774
401
45310
A300
F
N
G
V
P
M
V
A
S
S
P
V
R
H
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
29.7
73.6
99.1
N.A.
72.1
100
N.A.
52
99.4
30
97.9
N.A.
43.2
N.A.
N.A.
62
Protein Similarity:
100
46.5
83.8
99.1
N.A.
82.4
100
N.A.
52.3
100
47.3
99.1
N.A.
51.5
N.A.
N.A.
69.8
P-Site Identity:
100
6.6
60
100
N.A.
53.3
100
N.A.
100
100
6.6
93.3
N.A.
60
N.A.
N.A.
0
P-Site Similarity:
100
20
73.3
100
N.A.
66.6
100
N.A.
100
100
20
93.3
N.A.
73.3
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
75
42
9
0
0
0
0
0
0
17
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
17
0
0
0
0
0
0
0
0
0
59
0
9
% D
% Glu:
0
0
0
0
0
17
0
0
17
50
0
0
17
0
0
% E
% Phe:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
75
0
9
0
0
0
17
17
0
0
9
0
0
67
50
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
75
0
9
0
% H
% Ile:
0
9
0
0
9
0
0
0
0
17
17
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
17
0
0
17
17
0
0
0
0
17
0
0
0
0
0
% L
% Met:
0
0
0
59
0
9
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
9
0
0
0
0
0
0
0
0
0
0
17
17
0
% N
% Pro:
0
0
75
0
9
0
17
0
75
0
9
17
0
0
25
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
17
0
0
0
0
0
0
67
0
9
0
0
% R
% Ser:
0
0
0
0
0
0
9
75
9
9
0
0
0
9
0
% S
% Thr:
0
67
0
0
0
0
9
0
0
0
0
0
0
0
0
% T
% Val:
0
17
0
9
67
0
9
0
0
9
0
9
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _