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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ISL1
All Species:
32.12
Human Site:
S345
Identified Species:
64.24
UniProt:
P61371
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P61371
NP_002193.2
349
39036
S345
T
P
N
S
M
V
A
S
P
I
E
A
_
_
_
Chimpanzee
Pan troglodytes
Q5IS44
406
44776
L361
S
P
S
P
E
P
S
L
P
G
P
L
H
S
M
Rhesus Macaque
Macaca mulatta
XP_001104982
360
39837
S356
T
P
N
S
M
V
P
S
P
V
E
T
_
_
_
Dog
Lupus familis
XP_853721
346
38714
S342
T
P
N
S
M
V
A
S
P
I
E
A
_
_
_
Cat
Felis silvestris
Mouse
Mus musculus
Q9CXV0
359
39637
S355
T
P
N
S
M
V
P
S
P
V
E
T
_
_
_
Rat
Rattus norvegicus
P61374
349
39017
S345
T
P
N
S
M
V
A
S
P
I
E
A
_
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508080
665
71117
S661
T
P
N
S
M
V
A
S
P
I
E
A
_
_
_
Chicken
Gallus gallus
P50211
349
39015
S345
T
P
N
S
M
V
A
S
P
I
E
A
_
_
_
Frog
Xenopus laevis
P29674
403
44916
H393
G
Y
G
N
H
L
S
H
P
P
E
M
N
E
T
Zebra Danio
Brachydanio rerio
P53405
349
39162
S345
T
P
N
S
M
V
A
S
P
I
E
A
_
_
_
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_476775
534
58026
G406
P
H
S
H
P
A
Q
G
P
P
H
Q
H
P
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781774
401
45310
T380
S
G
M
S
L
P
P
T
P
D
S
S
D
R
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
29.7
73.6
99.1
N.A.
72.1
100
N.A.
52
99.4
30
97.9
N.A.
43.2
N.A.
N.A.
62
Protein Similarity:
100
46.5
83.8
99.1
N.A.
82.4
100
N.A.
52.3
100
47.3
99.1
N.A.
51.5
N.A.
N.A.
69.8
P-Site Identity:
100
13.3
75
100
N.A.
75
100
N.A.
100
100
13.3
100
N.A.
6.6
N.A.
N.A.
13.3
P-Site Similarity:
100
33.3
83.3
100
N.A.
83.3
100
N.A.
100
100
33.3
100
N.A.
13.3
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
9
50
0
0
0
0
50
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
9
0
0
9
0
0
% D
% Glu:
0
0
0
0
9
0
0
0
0
0
75
0
0
9
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
9
9
9
0
0
0
0
9
0
9
0
0
0
0
0
% G
% His:
0
9
0
9
9
0
0
9
0
0
9
0
17
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
50
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
9
9
0
9
0
0
0
9
0
0
0
% L
% Met:
0
0
9
0
67
0
0
0
0
0
0
9
0
0
17
% M
% Asn:
0
0
67
9
0
0
0
0
0
0
0
0
9
0
0
% N
% Pro:
9
75
0
9
9
17
25
0
100
17
9
0
0
9
9
% P
% Gln:
0
0
0
0
0
0
9
0
0
0
0
9
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% R
% Ser:
17
0
17
75
0
0
17
67
0
0
9
9
0
9
0
% S
% Thr:
67
0
0
0
0
0
0
9
0
0
0
17
0
0
9
% T
% Val:
0
0
0
0
0
67
0
0
0
17
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
67
67
67
% _