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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SEC61A1 All Species: 61.21
Human Site: S269 Identified Species: 96.19
UniProt: P61619 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P61619 NP_037468.1 476 52265 S269 R V D L P I K S A R Y R G Q Y
Chimpanzee Pan troglodytes XP_516725 587 64427 S380 R V D L P I K S A R Y R G Q Y
Rhesus Macaque Macaca mulatta XP_001098356 593 65043 S386 R V D L P I K S A R Y R G Q Y
Dog Lupus familis XP_535191 551 60482 S344 R V D L P I K S A R Y R G Q Y
Cat Felis silvestris
Mouse Mus musculus Q9JLR1 476 52229 S269 R V D L P I K S A R Y R G Q Y
Rat Rattus norvegicus P61621 476 52246 S269 R V D L P I K S A R Y R G Q Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506700 527 57384 S320 R V D L P I K S A R Y R G Q Y
Chicken Gallus gallus XP_414364 577 63158 S370 R V D L P I K S A R Y R G Q Y
Frog Xenopus laevis NP_001080244 476 52132 S269 R V D L P I K S A R Y R G Q Y
Zebra Danio Brachydanio rerio Q90ZM2 476 52279 S269 R V D L P I K S A R Y R G Q Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609034 476 52166 S269 R V D L P I K S A R Y R G Q Y
Honey Bee Apis mellifera XP_001120255 476 52370 S269 H V D L P I K S A R Y R G Q Y
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_802085 475 52232 S268 R V D L P I K S A R Y R G Q Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32915 480 52918 S271 R Y E L P I R S T K V R G Q I
Red Bread Mold Neurospora crassa Q870W0 476 52293 S271 R V E I P V K S S R Q R G A R
Conservation
Percent
Protein Identity: 100 81 80.2 80.9 N.A. 93.4 100 N.A. 89.9 81.9 97.9 97 N.A. 89.2 88 N.A. 89.2
Protein Similarity: 100 81 80.2 84 N.A. 97 100 N.A. 90.3 82.3 99.1 98.7 N.A. 94.9 95.1 N.A. 94.9
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 100 100 100 100 N.A. 100 93.3 N.A. 100
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 100 100 N.A. 100 93.3 N.A. 100
Percent
Protein Identity: N.A. N.A. N.A. N.A. 55 64
Protein Similarity: N.A. N.A. N.A. N.A. 72.5 80.2
P-Site Identity: N.A. N.A. N.A. N.A. 53.3 53.3
P-Site Similarity: N.A. N.A. N.A. N.A. 73.3 80
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 87 0 0 0 0 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 87 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 14 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 % G
% His: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 7 0 94 0 0 0 0 0 0 0 0 7 % I
% Lys: 0 0 0 0 0 0 94 0 0 7 0 0 0 0 0 % K
% Leu: 0 0 0 94 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 7 0 0 94 0 % Q
% Arg: 94 0 0 0 0 0 7 0 0 94 0 100 0 0 7 % R
% Ser: 0 0 0 0 0 0 0 100 7 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % T
% Val: 0 94 0 0 0 7 0 0 0 0 7 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 0 0 0 0 0 0 0 0 87 0 0 0 87 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _