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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SEC61A1 All Species: 56.67
Human Site: T105 Identified Species: 89.05
UniProt: P61619 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P61619 NP_037468.1 476 52265 T105 K I I E V G D T P K D R A L F
Chimpanzee Pan troglodytes XP_516725 587 64427 T216 K I I E V G D T P K D R A L F
Rhesus Macaque Macaca mulatta XP_001098356 593 65043 T222 K I I E V G D T P K D R A L F
Dog Lupus familis XP_535191 551 60482 T180 K I I E V G D T P K D R A L F
Cat Felis silvestris
Mouse Mus musculus Q9JLR1 476 52229 T105 K I I E V G D T P K D R A L F
Rat Rattus norvegicus P61621 476 52246 T105 K I I E V G D T P K D R A L F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506700 527 57384 T156 K I I E V G D T P K D R A L F
Chicken Gallus gallus XP_414364 577 63158 T206 K I I E V G D T P K D R A L F
Frog Xenopus laevis NP_001080244 476 52132 T105 K I I E V G D T P K D R A L F
Zebra Danio Brachydanio rerio Q90ZM2 476 52279 T105 K I I E V G D T P K D R A L F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609034 476 52166 T105 K I I E V G D T P K D R A L F
Honey Bee Apis mellifera XP_001120255 476 52370 T105 K I I E V G D T P K D R A L F
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_802085 475 52232 T104 K I I E V G D T A K D R A L F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32915 480 52918 S107 L L Q I R P E S K Q D R E L F
Red Bread Mold Neurospora crassa Q870W0 476 52293 L107 M I D V N L D L K A D R E L Y
Conservation
Percent
Protein Identity: 100 81 80.2 80.9 N.A. 93.4 100 N.A. 89.9 81.9 97.9 97 N.A. 89.2 88 N.A. 89.2
Protein Similarity: 100 81 80.2 84 N.A. 97 100 N.A. 90.3 82.3 99.1 98.7 N.A. 94.9 95.1 N.A. 94.9
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 100 100 100 100 N.A. 100 100 N.A. 93.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 100 100 N.A. 100 100 N.A. 93.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 55 64
Protein Similarity: N.A. N.A. N.A. N.A. 72.5 80.2
P-Site Identity: N.A. N.A. N.A. N.A. 26.6 33.3
P-Site Similarity: N.A. N.A. N.A. N.A. 53.3 40
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 7 7 0 0 87 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 7 0 0 0 94 0 0 0 100 0 0 0 0 % D
% Glu: 0 0 0 87 0 0 7 0 0 0 0 0 14 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 94 % F
% Gly: 0 0 0 0 0 87 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 94 87 7 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 87 0 0 0 0 0 0 0 14 87 0 0 0 0 0 % K
% Leu: 7 7 0 0 0 7 0 7 0 0 0 0 0 100 0 % L
% Met: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 7 0 0 80 0 0 0 0 0 0 % P
% Gln: 0 0 7 0 0 0 0 0 0 7 0 0 0 0 0 % Q
% Arg: 0 0 0 0 7 0 0 0 0 0 0 100 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 87 0 0 0 0 0 0 0 % T
% Val: 0 0 0 7 87 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _