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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: STXBP1 All Species: 50.3
Human Site: S241 Identified Species: 79.05
UniProt: P61764 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P61764 NP_001027392.1 594 67569 S241 D R G F D P S S P V L H E L T
Chimpanzee Pan troglodytes XP_001152683 595 67000 S243 D R A A D P V S P L L H E L T
Rhesus Macaque Macaca mulatta XP_001095617 580 66142 S227 D R G F D P S S P V L H E L T
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q64324 593 66339 S241 D R A A D P V S P L L H E L T
Rat Rattus norvegicus P61765 594 67550 S241 D R G F D P S S P V L H E L T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508183 589 67400 S227 D R G F D P S S P V L H E L T
Chicken Gallus gallus Q6R748 594 67454 S241 D R G F D P A S P V L H E L T
Frog Xenopus laevis NP_001093335 595 67691 S241 D R G F D P A S P I L H E L T
Zebra Danio Brachydanio rerio NP_001020353 591 67111 S241 D R G F D P V S P V L H E L T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q07327 597 67832 S252 D R G F D C V S P L L H E L T
Honey Bee Apis mellifera XP_396375 585 66573 S241 D R G F D C V S P L L H E L T
Nematode Worm Caenorhab. elegans P34815 673 76715 T321 D R G Y D A I T P L L H E L T
Sea Urchin Strong. purpuratus NP_999834 593 68046 S238 D R G F D P V S P L L H E L T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SZ77 662 75299 A266 D R S I D Q I A P L I H E W T
Baker's Yeast Sacchar. cerevisiae P30619 724 83462 A258 D R T L D P F A P I L H D F S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 63.8 97.6 N.A. N.A. 62.7 100 N.A. 93.4 97.9 92.4 86.5 N.A. 63.4 63.9 52.1 60.9
Protein Similarity: 100 81.1 97.6 N.A. N.A. 80.6 100 N.A. 96.1 99.4 97.9 94.6 N.A. 78 79.6 67.4 77.7
P-Site Identity: 100 73.3 100 N.A. N.A. 73.3 100 N.A. 100 93.3 86.6 93.3 N.A. 80 80 66.6 86.6
P-Site Similarity: 100 80 100 N.A. N.A. 80 100 N.A. 100 100 100 93.3 N.A. 86.6 86.6 86.6 93.3
Percent
Protein Identity: N.A. N.A. N.A. 28.2 22.7 N.A.
Protein Similarity: N.A. N.A. N.A. 51.2 42.8 N.A.
P-Site Identity: N.A. N.A. N.A. 46.6 46.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 66.6 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 14 14 0 7 14 14 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 14 0 0 0 0 0 0 0 0 0 % C
% Asp: 100 0 0 0 100 0 0 0 0 0 0 0 7 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 94 0 0 % E
% Phe: 0 0 0 67 0 0 7 0 0 0 0 0 0 7 0 % F
% Gly: 0 0 74 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 % H
% Ile: 0 0 0 7 0 0 14 0 0 14 7 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 7 0 0 0 0 0 47 94 0 0 87 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 74 0 0 100 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 7 0 0 0 27 80 0 0 0 0 0 0 7 % S
% Thr: 0 0 7 0 0 0 0 7 0 0 0 0 0 0 94 % T
% Val: 0 0 0 0 0 0 40 0 0 40 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % W
% Tyr: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _