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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NPC2
All Species:
9.09
Human Site:
T44
Identified Species:
28.57
UniProt:
P61916
Number Species:
7
Phosphosite Substitution
Charge Score:
0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P61916
NP_006423.1
151
16570
T44
V
N
V
S
P
C
P
T
Q
P
C
Q
L
S
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_855001
149
16093
T44
L
N
V
N
P
C
P
T
Q
P
C
K
L
H
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0J0
149
16424
T44
V
N
V
S
P
C
P
T
D
P
C
Q
L
H
K
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026374
148
16201
L48
C
P
T
Q
P
C
Q
L
V
K
G
T
S
Y
S
Frog
Xenopus laevis
NP_001084605
151
16430
E45
L
D
V
S
P
C
P
E
Q
P
C
P
L
K
R
Zebra Danio
Brachydanio rerio
Q9DGJ3
149
16287
Q44
V
D
I
K
P
C
S
Q
Q
P
C
K
L
H
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VQ62
148
16002
E45
G
C
D
T
T
K
A
E
C
I
L
K
R
N
T
Honey Bee
Apis mellifera
XP_624310
135
14956
T40
L
I
P
D
T
N
A
T
I
R
I
D
F
T
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
78.8
N.A.
80.1
N.A.
N.A.
N.A.
68.8
58.2
57.6
N.A.
33.7
33.7
N.A.
N.A.
Protein Similarity:
100
N.A.
N.A.
84.7
N.A.
87.4
N.A.
N.A.
N.A.
81.4
74.1
76.8
N.A.
54.2
52.3
N.A.
N.A.
P-Site Identity:
100
N.A.
N.A.
73.3
N.A.
86.6
N.A.
N.A.
N.A.
13.3
60
53.3
N.A.
0
6.6
N.A.
N.A.
P-Site Similarity:
100
N.A.
N.A.
93.3
N.A.
86.6
N.A.
N.A.
N.A.
13.3
80
73.3
N.A.
20
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
25
0
0
0
0
0
0
0
0
% A
% Cys:
13
13
0
0
0
75
0
0
13
0
63
0
0
0
0
% C
% Asp:
0
25
13
13
0
0
0
0
13
0
0
13
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
25
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
13
0
0
% F
% Gly:
13
0
0
0
0
0
0
0
0
0
13
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
38
0
% H
% Ile:
0
13
13
0
0
0
0
0
13
13
13
0
0
0
0
% I
% Lys:
0
0
0
13
0
13
0
0
0
13
0
38
0
13
50
% K
% Leu:
38
0
0
0
0
0
0
13
0
0
13
0
63
0
13
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
38
0
13
0
13
0
0
0
0
0
0
0
13
0
% N
% Pro:
0
13
13
0
75
0
50
0
0
63
0
13
0
0
0
% P
% Gln:
0
0
0
13
0
0
13
13
50
0
0
25
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
13
0
0
13
0
13
% R
% Ser:
0
0
0
38
0
0
13
0
0
0
0
0
13
13
13
% S
% Thr:
0
0
13
13
25
0
0
50
0
0
0
13
0
13
13
% T
% Val:
38
0
50
0
0
0
0
0
13
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
13
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _