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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WDR5
All Species:
27.88
Human Site:
S106
Identified Species:
51.11
UniProt:
P61964
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P61964
NP_060058.1
334
36588
S106
S
N
L
L
V
S
A
S
D
D
K
T
L
K
I
Chimpanzee
Pan troglodytes
Q5IS43
410
46712
S169
G
K
L
L
A
S
C
S
A
D
M
T
I
K
L
Rhesus Macaque
Macaca mulatta
XP_001112263
330
36273
D103
S
R
L
V
S
A
S
D
D
K
T
L
K
L
W
Dog
Lupus familis
XP_850117
334
36428
S106
S
N
L
L
V
S
A
S
D
D
K
T
L
K
I
Cat
Felis silvestris
Mouse
Mus musculus
Q9D7H2
328
36014
D101
S
R
L
V
S
A
S
D
D
K
T
L
K
V
W
Rat
Rattus norvegicus
Q4V8C4
328
36030
D101
S
R
L
V
S
A
S
D
D
K
T
L
K
L
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506016
334
36605
S106
S
N
L
L
V
S
A
S
D
D
K
T
L
K
I
Chicken
Gallus gallus
Q9PTR5
410
46646
S169
G
K
L
L
A
S
C
S
A
D
M
T
I
K
L
Frog
Xenopus laevis
Q90ZL4
410
46744
S169
G
K
L
L
A
S
C
S
A
D
M
T
I
K
L
Zebra Danio
Brachydanio rerio
Q803D2
410
46511
S169
G
K
L
L
A
S
C
S
A
D
M
T
I
K
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3J8
361
39023
S133
S
R
L
L
V
S
G
S
D
D
K
T
L
K
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17963
376
40375
S148
S
R
C
V
V
S
A
S
D
D
K
T
L
K
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38123
315
34735
L88
I
I
H
L
S
Y
G
L
L
H
T
F
I
G
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
27
84.7
96.4
N.A.
79
80.5
N.A.
97.9
27
28
28
N.A.
82.5
N.A.
61.7
N.A.
Protein Similarity:
100
45.8
90.7
97.9
N.A.
88.3
88.6
N.A.
98.1
46.5
46.3
46.5
N.A.
87.5
N.A.
74.4
N.A.
P-Site Identity:
100
46.6
20
100
N.A.
20
20
N.A.
100
46.6
46.6
46.6
N.A.
80
N.A.
80
N.A.
P-Site Similarity:
100
60
40
100
N.A.
40
40
N.A.
100
60
60
60
N.A.
86.6
N.A.
86.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
31
24
31
0
31
0
0
0
0
0
0
% A
% Cys:
0
0
8
0
0
0
31
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
24
62
70
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% F
% Gly:
31
0
0
0
0
0
16
0
0
0
0
0
0
8
0
% G
% His:
0
0
8
0
0
0
0
0
0
8
0
0
0
0
8
% H
% Ile:
8
8
0
0
0
0
0
0
0
0
0
0
39
0
31
% I
% Lys:
0
31
0
0
0
0
0
0
0
24
39
0
24
70
0
% K
% Leu:
0
0
85
70
0
0
0
8
8
0
0
24
39
16
31
% L
% Met:
0
0
0
0
0
0
0
0
0
0
31
0
0
0
0
% M
% Asn:
0
24
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
39
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
62
0
0
0
31
70
24
70
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
31
70
0
0
0
% T
% Val:
0
0
0
31
39
0
0
0
0
0
0
0
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
24
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _