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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WDR5
All Species:
13.64
Human Site:
Y243
Identified Species:
25
UniProt:
P61964
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.42
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P61964
NP_060058.1
334
36588
Y243
N
T
L
K
L
W
D
Y
S
K
G
K
C
L
K
Chimpanzee
Pan troglodytes
Q5IS43
410
46712
K306
S
E
T
K
K
S
G
K
P
G
P
F
L
L
S
Rhesus Macaque
Macaca mulatta
XP_001112263
330
36273
S240
T
L
K
L
W
D
Y
S
R
G
R
C
L
K
T
Dog
Lupus familis
XP_850117
334
36428
Y243
N
T
L
K
L
W
D
Y
S
K
G
K
C
L
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9D7H2
328
36014
S238
T
L
K
L
W
D
Y
S
R
G
R
C
L
K
T
Rat
Rattus norvegicus
Q4V8C4
328
36030
S238
T
L
K
L
W
D
Y
S
R
G
R
C
L
K
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506016
334
36605
Y243
N
T
L
K
L
W
D
Y
S
K
G
K
C
L
K
Chicken
Gallus gallus
Q9PTR5
410
46646
K306
S
E
T
K
K
S
G
K
P
G
P
F
L
L
S
Frog
Xenopus laevis
Q90ZL4
410
46744
K306
S
E
T
K
R
S
G
K
P
G
P
F
L
L
S
Zebra Danio
Brachydanio rerio
Q803D2
410
46511
K306
S
E
N
K
K
S
G
K
P
G
P
F
L
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3J8
361
39023
Y270
N
T
L
K
L
W
D
Y
S
K
G
K
C
L
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17963
376
40375
F285
S
T
L
K
L
W
D
F
S
K
G
K
T
L
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38123
315
34735
R225
C
I
G
G
C
V
V
R
T
F
Q
V
Q
P
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
27
84.7
96.4
N.A.
79
80.5
N.A.
97.9
27
28
28
N.A.
82.5
N.A.
61.7
N.A.
Protein Similarity:
100
45.8
90.7
97.9
N.A.
88.3
88.6
N.A.
98.1
46.5
46.3
46.5
N.A.
87.5
N.A.
74.4
N.A.
P-Site Identity:
100
13.3
0
100
N.A.
0
0
N.A.
100
13.3
13.3
13.3
N.A.
100
N.A.
80
N.A.
P-Site Similarity:
100
20
0
100
N.A.
0
0
N.A.
100
20
20
20
N.A.
100
N.A.
93.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
8
0
0
0
8
0
0
0
0
0
0
24
31
0
0
% C
% Asp:
0
0
0
0
0
24
39
0
0
0
0
0
0
0
0
% D
% Glu:
0
31
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
8
0
31
0
0
0
% F
% Gly:
0
0
8
8
0
0
31
0
0
54
39
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
24
70
24
0
0
31
0
39
0
39
0
24
39
% K
% Leu:
0
24
39
24
39
0
0
0
0
0
0
0
54
70
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
31
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
31
0
31
0
0
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
8
0
8
0
0
% Q
% Arg:
0
0
0
0
8
0
0
8
24
0
24
0
0
0
0
% R
% Ser:
39
0
0
0
0
31
0
24
39
0
0
0
0
0
31
% S
% Thr:
24
39
24
0
0
0
0
0
8
0
0
0
8
0
24
% T
% Val:
0
0
0
0
0
8
8
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
24
39
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
24
31
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _