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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AP1S1 All Species: 31.21
Human Site: S48 Identified Species: 49.05
UniProt: P61966 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P61966 NP_001274.1 158 18733 S48 A R K P K M C S F L E W R D L
Chimpanzee Pan troglodytes XP_001138231 185 21159 A78 E L V Q T V L A R K P K M C S
Rhesus Macaque Macaca mulatta XP_001102358 160 19119 S47 A R K P K M C S F L E W R D L
Dog Lupus familis XP_854230 349 39164 S236 A R K P K M C S F L E W R D L
Cat Felis silvestris
Mouse Mus musculus Q9DB50 160 18911 S47 A R K P K M C S F L E W R D L
Rat Rattus norvegicus P62744 142 16999 V35 K Q K L I E E V H A V V T V R
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001006261 157 18595 S47 A R K P K M C S F L E W R D L
Frog Xenopus laevis NP_001083719 157 18689 S47 S R K P K M C S F L E W K D F
Zebra Danio Brachydanio rerio NP_991121 157 18590 S47 A R K P K M C S F L E W R D L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651198 157 18555 S48 A R K P K M C S F L E W K D C
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_504559 157 18615 A48 A R K P K M C A F L E Y K D L
Sea Urchin Strong. purpuratus XP_001203214 158 18892 N48 T R K P K M C N F L E W R D Y
Poplar Tree Populus trichocarpa
Maize Zea mays O50016 132 15996 D25 K Y Y V P L E D S E K H K V E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P35181 156 18134 R44 L T P T I L A R K P K M C N I
Red Bread Mold Neurospora crassa Q7SAQ1 143 16937 H36 I K L K G E I H R L V A P R D
Conservation
Percent
Protein Identity: 100 68.6 80.6 39.2 N.A. 85 42.4 N.A. N.A. 86 86.7 81 N.A. 76.5 N.A. 75.9 74
Protein Similarity: 100 75.6 88.7 43.5 N.A. 94.3 65.1 N.A. N.A. 94.9 96.1 94.3 N.A. 87.9 N.A. 87.9 87.3
P-Site Identity: 100 0 100 100 N.A. 100 6.6 N.A. N.A. 100 80 100 N.A. 86.6 N.A. 80 80
P-Site Similarity: 100 13.3 100 100 N.A. 100 13.3 N.A. N.A. 100 93.3 100 N.A. 93.3 N.A. 100 86.6
Percent
Protein Identity: N.A. 39.8 N.A. N.A. 52.5 45.5
Protein Similarity: N.A. 60.1 N.A. N.A. 73.4 66.4
P-Site Identity: N.A. 0 N.A. N.A. 0 6.6
P-Site Similarity: N.A. 20 N.A. N.A. 26.6 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 54 0 0 0 0 0 7 14 0 7 0 7 0 0 0 % A
% Cys: 0 0 0 0 0 0 67 0 0 0 0 0 7 7 7 % C
% Asp: 0 0 0 0 0 0 0 7 0 0 0 0 0 67 7 % D
% Glu: 7 0 0 0 0 14 14 0 0 7 67 0 0 0 7 % E
% Phe: 0 0 0 0 0 0 0 0 67 0 0 0 0 0 7 % F
% Gly: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 7 7 0 0 7 0 0 0 % H
% Ile: 7 0 0 0 14 0 7 0 0 0 0 0 0 0 7 % I
% Lys: 14 7 74 7 67 0 0 0 7 7 14 7 27 0 0 % K
% Leu: 7 7 7 7 0 14 7 0 0 74 0 0 0 0 47 % L
% Met: 0 0 0 0 0 67 0 0 0 0 0 7 7 0 0 % M
% Asn: 0 0 0 0 0 0 0 7 0 0 0 0 0 7 0 % N
% Pro: 0 0 7 67 7 0 0 0 0 7 7 0 7 0 0 % P
% Gln: 0 7 0 7 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 67 0 0 0 0 0 7 14 0 0 0 47 7 7 % R
% Ser: 7 0 0 0 0 0 0 54 7 0 0 0 0 0 7 % S
% Thr: 7 7 0 7 7 0 0 0 0 0 0 0 7 0 0 % T
% Val: 0 0 7 7 0 7 0 7 0 0 14 7 0 14 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 60 0 0 0 % W
% Tyr: 0 7 7 0 0 0 0 0 0 0 0 7 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _