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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AP1S1 All Species: 37.27
Human Site: T80 Identified Species: 58.57
UniProt: P61966 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P61966 NP_001274.1 158 18733 T80 G Q D N E L I T L E L I H R Y
Chimpanzee Pan troglodytes XP_001138231 185 21159 D110 Y F C C A I E D Q D N E L I T
Rhesus Macaque Macaca mulatta XP_001102358 160 19119 T79 D Q D N E L I T L E I I H R Y
Dog Lupus familis XP_854230 349 39164 T268 D Q D N E L I T L E I I H R Y
Cat Felis silvestris
Mouse Mus musculus Q9DB50 160 18911 T79 D Q D N E L I T L E I I H R Y
Rat Rattus norvegicus P62744 142 16999 F67 R R Y A G L Y F C I C V D V N
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001006261 157 18595 T79 D Q D N E L I T L E I I H R Y
Frog Xenopus laevis NP_001083719 157 18689 T79 D Q D N E L L T L E L I H R Y
Zebra Danio Brachydanio rerio NP_991121 157 18590 T79 D Q E N E L I T L E I I H R Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651198 157 18555 T80 Q N D N E L L T L E I I H R Y
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_504559 157 18615 T80 Q N D N E L I T L E V I H R Y
Sea Urchin Strong. purpuratus XP_001203214 158 18892 T80 E N D N E L L T L E I I H R Y
Poplar Tree Populus trichocarpa
Maize Zea mays O50016 132 15996 V57 V E F R T H K V I Y R R Y A G
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P35181 156 18134 D76 F I V G M T P D V D N E L L T
Red Bread Mold Neurospora crassa Q7SAQ1 143 16937 F68 R R Y A G L F F C A C V D T N
Conservation
Percent
Protein Identity: 100 68.6 80.6 39.2 N.A. 85 42.4 N.A. N.A. 86 86.7 81 N.A. 76.5 N.A. 75.9 74
Protein Similarity: 100 75.6 88.7 43.5 N.A. 94.3 65.1 N.A. N.A. 94.9 96.1 94.3 N.A. 87.9 N.A. 87.9 87.3
P-Site Identity: 100 0 86.6 86.6 N.A. 86.6 6.6 N.A. N.A. 86.6 86.6 80 N.A. 73.3 N.A. 80 73.3
P-Site Similarity: 100 13.3 93.3 93.3 N.A. 93.3 20 N.A. N.A. 93.3 93.3 93.3 N.A. 86.6 N.A. 86.6 86.6
Percent
Protein Identity: N.A. 39.8 N.A. N.A. 52.5 45.5
Protein Similarity: N.A. 60.1 N.A. N.A. 73.4 66.4
P-Site Identity: N.A. 0 N.A. N.A. 0 6.6
P-Site Similarity: N.A. 20 N.A. N.A. 13.3 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 14 7 0 0 0 0 7 0 0 0 7 0 % A
% Cys: 0 0 7 7 0 0 0 0 14 0 14 0 0 0 0 % C
% Asp: 40 0 60 0 0 0 0 14 0 14 0 0 14 0 0 % D
% Glu: 7 7 7 0 67 0 7 0 0 67 0 14 0 0 0 % E
% Phe: 7 7 7 0 0 0 7 14 0 0 0 0 0 0 0 % F
% Gly: 7 0 0 7 14 0 0 0 0 0 0 0 0 0 7 % G
% His: 0 0 0 0 0 7 0 0 0 0 0 0 67 0 0 % H
% Ile: 0 7 0 0 0 7 47 0 7 7 47 67 0 7 0 % I
% Lys: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 80 20 0 67 0 14 0 14 7 0 % L
% Met: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 20 0 67 0 0 0 0 0 0 14 0 0 0 14 % N
% Pro: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % P
% Gln: 14 47 0 0 0 0 0 0 7 0 0 0 0 0 0 % Q
% Arg: 14 14 0 7 0 0 0 0 0 0 7 7 0 67 0 % R
% Ser: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 7 7 0 67 0 0 0 0 0 7 14 % T
% Val: 7 0 7 0 0 0 0 7 7 0 7 14 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 0 14 0 0 0 7 0 0 7 0 0 7 0 67 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _