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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PPP1CB
All Species:
49.39
Human Site:
Y77
Identified Species:
83.59
UniProt:
P62140
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P62140
NP_002700.1
327
37187
Y77
D
L
L
R
L
F
E
Y
G
G
F
P
P
E
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001101758
299
34103
R67
F
L
G
D
Y
V
D
R
G
K
Q
S
L
E
T
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P62137
330
37522
Y78
D
L
L
R
L
F
E
Y
G
G
F
P
P
E
S
Rat
Rattus norvegicus
P62138
330
37494
Y78
D
L
L
R
L
F
E
Y
G
G
F
P
P
E
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q7SZ10
323
36919
Y78
D
L
L
R
L
F
E
Y
G
G
F
P
P
E
S
Zebra Danio
Brachydanio rerio
NP_001004527
327
37123
Y77
D
L
L
R
L
F
E
Y
G
G
F
P
P
E
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48462
330
37722
Y77
D
L
L
R
L
F
E
Y
G
G
F
P
P
A
A
Honey Bee
Apis mellifera
XP_393296
328
37531
Y77
D
L
L
R
L
F
E
Y
G
G
F
P
P
E
A
Nematode Worm
Caenorhab. elegans
P48727
333
37773
Y77
D
L
L
R
L
F
E
Y
G
G
F
P
P
E
S
Sea Urchin
Strong. purpuratus
XP_001175801
324
36856
Y76
D
L
L
R
L
F
E
Y
G
G
F
P
P
D
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P22198
316
35745
Y75
D
L
L
R
L
F
D
Y
G
G
Y
P
P
Q
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P48484
321
36353
Y88
D
L
L
R
L
F
E
Y
G
G
F
P
P
S
A
Baker's Yeast
Sacchar. cerevisiae
P32598
312
35889
Y77
D
L
L
R
L
F
E
Y
G
G
F
P
P
E
S
Red Bread Mold
Neurospora crassa
Q9UW86
308
35549
L72
I
H
G
Q
Y
Y
D
L
L
R
L
F
E
Y
G
Conservation
Percent
Protein Identity:
100
N.A.
91.4
N.A.
N.A.
88.4
88.7
N.A.
N.A.
N.A.
87.7
97.2
N.A.
88.7
90.8
85.5
89.3
Protein Similarity:
100
N.A.
91.4
N.A.
N.A.
94.2
94.2
N.A.
N.A.
N.A.
92.6
98.7
N.A.
93.3
94.5
92.7
94.8
P-Site Identity:
100
N.A.
20
N.A.
N.A.
93.3
93.3
N.A.
N.A.
N.A.
93.3
100
N.A.
93.3
100
93.3
86.6
P-Site Similarity:
100
N.A.
26.6
N.A.
N.A.
100
100
N.A.
N.A.
N.A.
100
100
N.A.
93.3
100
100
100
Percent
Protein Identity:
N.A.
71.5
N.A.
74.6
77.6
81.3
Protein Similarity:
N.A.
83.7
N.A.
84.4
86.5
88.3
P-Site Identity:
N.A.
80
N.A.
93.3
93.3
0
P-Site Similarity:
N.A.
100
N.A.
93.3
100
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
43
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
86
0
0
8
0
0
22
0
0
0
0
0
0
8
0
% D
% Glu:
0
0
0
0
0
0
79
0
0
0
0
0
8
65
0
% E
% Phe:
8
0
0
0
0
86
0
0
0
0
79
8
0
0
0
% F
% Gly:
0
0
15
0
0
0
0
0
93
86
0
0
0
0
8
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% K
% Leu:
0
93
86
0
86
0
0
8
8
0
8
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
86
86
0
0
% P
% Gln:
0
0
0
8
0
0
0
0
0
0
8
0
0
8
0
% Q
% Arg:
0
0
0
86
0
0
0
8
0
8
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
8
0
8
43
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% T
% Val:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
15
8
0
86
0
0
8
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _