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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLR2G All Species: 43.64
Human Site: S109 Identified Species: 87.27
UniProt: P62487 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P62487 NP_002687.1 172 19294 S109 G P M S C F I S R H S I P S E
Chimpanzee Pan troglodytes XP_001142605 227 25089 S164 G P M S C F I S R H S I P S E
Rhesus Macaque Macaca mulatta XP_001116154 221 24489 S158 G P M S C F I S R H S I P S E
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus
Rat Rattus norvegicus P62489 172 19276 S109 G P M S C F I S R H S I P S E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q7ZW41 172 19230 S109 G P M S C F I S R H S I P S E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624976 169 18644 S105 G P L S C F I S H H S I P A D
Nematode Worm Caenorhab. elegans NP_491093 197 22076 S132 G P L S C F I S R H C I P P D
Sea Urchin Strong. purpuratus XP_780458 172 19146 S109 G P L S C F I S R H S I P A D
Poplar Tree Populus trichocarpa XP_002298912 176 19617 S109 G P V Q I F V S N H L I P D D
Maize Zea mays NP_001149597 177 19553 S109 G P V Q I F V S N H L I P D D
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P38421 176 19443 S109 G P V Q I F V S K H L I P D D
Baker's Yeast Sacchar. cerevisiae P34087 171 19040 T111 G P M K V F V T K H L M P Q D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 74.8 76.4 N.A. N.A. N.A. 100 N.A. N.A. N.A. N.A. 98.8 N.A. N.A. 81.4 67 92.4
Protein Similarity: 100 75.3 76.9 N.A. N.A. N.A. 100 N.A. N.A. N.A. N.A. 100 N.A. N.A. 91.8 77.1 98.2
P-Site Identity: 100 100 100 N.A. N.A. N.A. 100 N.A. N.A. N.A. N.A. 100 N.A. N.A. 73.3 73.3 80
P-Site Similarity: 100 100 100 N.A. N.A. N.A. 100 N.A. N.A. N.A. N.A. 100 N.A. N.A. 93.3 86.6 100
Percent
Protein Identity: 53.4 51.4 N.A. 52.2 43 N.A.
Protein Similarity: 73.3 74.5 N.A. 72.7 62.7 N.A.
P-Site Identity: 46.6 46.6 N.A. 46.6 40 N.A.
P-Site Similarity: 66.6 66.6 N.A. 73.3 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 17 0 % A
% Cys: 0 0 0 0 67 0 0 0 0 0 9 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 25 59 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 42 % E
% Phe: 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 % F
% Gly: 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 9 100 0 0 0 0 0 % H
% Ile: 0 0 0 0 25 0 67 0 0 0 0 92 0 0 0 % I
% Lys: 0 0 0 9 0 0 0 0 17 0 0 0 0 0 0 % K
% Leu: 0 0 25 0 0 0 0 0 0 0 34 0 0 0 0 % L
% Met: 0 0 50 0 0 0 0 0 0 0 0 9 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 17 0 0 0 0 0 0 % N
% Pro: 0 100 0 0 0 0 0 0 0 0 0 0 100 9 0 % P
% Gln: 0 0 0 25 0 0 0 0 0 0 0 0 0 9 0 % Q
% Arg: 0 0 0 0 0 0 0 0 59 0 0 0 0 0 0 % R
% Ser: 0 0 0 67 0 0 0 92 0 0 59 0 0 42 0 % S
% Thr: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % T
% Val: 0 0 25 0 9 0 34 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _