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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLR2L All Species: 39.95
Human Site: Y62 Identified Species: 87.9
UniProt: P62875 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P62875 NP_066951.1 67 7645 Y62 L I E K L L N Y A P L E K _ _
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus XP_001480836 67 7626 Y62 L I E K L L N Y A P L E K _ _
Rat Rattus norvegicus XP_002728623 67 7564 Y62 L I E K L L N Y A P L E K _ _
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001153297 67 7643 Y62 L I E K L L N Y A P L E K _ _
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VC49 67 7643 Y62 L I E K L L N Y A P L E K _ _
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9GR61 67 7802 Y62 L I E K L L N Y H P L E K _ _
Sea Urchin Strong. purpuratus XP_790633 67 7599 Y62 L I E K L L N Y A P L E K _ _
Poplar Tree Populus trichocarpa XP_002326311 71 8113 Y62 L I E K L L N Y N T L E K S E
Maize Zea mays NP_001148175 242 27752 Y233 L I E K L L N Y N T L E K T E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SYA6 71 8154 Y62 L I E K L L N Y N T M E K S D
Baker's Yeast Sacchar. cerevisiae P22139 70 8259 Y63 L I E K F L R Y N P L E K R D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. N.A. N.A. 98.5 95.5 N.A. N.A. N.A. N.A. 98.5 N.A. 92.5 N.A. 85 97
Protein Similarity: 100 N.A. N.A. N.A. N.A. 100 97 N.A. N.A. N.A. N.A. 100 N.A. 98.5 N.A. 95.5 100
P-Site Identity: 100 N.A. N.A. N.A. N.A. 100 100 N.A. N.A. N.A. N.A. 100 N.A. 100 N.A. 92.3 100
P-Site Similarity: 100 N.A. N.A. N.A. N.A. 100 100 N.A. N.A. N.A. N.A. 100 N.A. 100 N.A. 92.3 100
Percent
Protein Identity: 78.8 22.3 N.A. 74.6 71.4 N.A.
Protein Similarity: 85.9 24.7 N.A. 84.5 80 N.A.
P-Site Identity: 73.3 73.3 N.A. 66.6 66.6 N.A.
P-Site Similarity: 73.3 73.3 N.A. 73.3 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 55 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 19 % D
% Glu: 0 0 100 0 0 0 0 0 0 0 0 100 0 0 19 % E
% Phe: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % H
% Ile: 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 100 0 0 0 0 0 0 0 0 100 0 0 % K
% Leu: 100 0 0 0 91 100 0 0 0 0 91 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 91 0 37 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 73 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 10 0 0 0 0 0 0 10 0 % R
% Ser: 0 0 0 0 0 0 0 0 0 0 0 0 0 19 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 28 0 0 0 10 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 64 64 % _