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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GRB2
All Species:
35.15
Human Site:
Y134
Identified Species:
64.44
UniProt:
P62993
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P62993
NP_002077.1
217
25206
Y134
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
Chimpanzee
Pan troglodytes
XP_001141222
145
16765
E80
Q
I
F
L
R
D
I
E
Q
V
P
Q
Q
P
T
Rhesus Macaque
Macaca mulatta
XP_001097817
217
25285
F134
S
L
N
E
L
V
D
F
Y
R
T
T
T
I
A
Dog
Lupus familis
XP_546653
217
25309
F134
S
L
N
E
L
V
D
F
Y
R
T
T
T
I
A
Cat
Felis silvestris
Mouse
Mus musculus
Q60631
217
25220
Y134
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
Rat
Rattus norvegicus
P62994
217
25188
Y134
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505729
215
25238
F134
S
L
N
E
L
V
D
F
Y
R
T
T
T
I
A
Chicken
Gallus gallus
Q07883
217
25058
Y134
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
Frog
Xenopus laevis
Q6GPJ9
229
26344
Y134
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
Zebra Danio
Brachydanio rerio
NP_998200
217
25269
Y134
S
L
N
E
L
V
D
Y
H
R
T
T
S
V
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q08012
211
24417
Y133
S
L
N
E
L
V
E
Y
H
R
T
A
S
V
S
Honey Bee
Apis mellifera
XP_623354
211
24679
Y133
S
L
N
E
L
V
E
Y
H
R
T
A
S
V
S
Nematode Worm
Caenorhab. elegans
P29355
228
26192
Y135
S
L
N
E
L
V
A
Y
H
R
T
A
S
V
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
66.8
59.4
58
N.A.
99.5
100
N.A.
54.8
96.3
91.2
94.9
N.A.
64
62.2
56.1
N.A.
Protein Similarity:
100
66.8
78.8
76.9
N.A.
100
100
N.A.
72.8
97.6
93
98.6
N.A.
77.4
76.5
71.4
N.A.
P-Site Identity:
100
0
60
60
N.A.
100
100
N.A.
60
100
100
93.3
N.A.
80
80
80
N.A.
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
93.3
93.3
86.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
0
0
0
0
24
0
0
24
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
8
70
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
93
0
0
16
8
0
0
0
0
0
0
0
% E
% Phe:
0
0
8
0
0
0
0
24
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
70
0
0
0
0
0
0
% H
% Ile:
0
8
0
0
0
0
8
0
0
0
0
0
0
24
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
93
0
8
93
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
93
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
0
% P
% Gln:
8
0
0
0
0
0
0
0
8
0
0
8
8
0
0
% Q
% Arg:
0
0
0
0
8
0
0
0
0
93
0
0
0
0
0
% R
% Ser:
93
0
0
0
0
0
0
0
0
0
39
0
70
0
70
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
54
70
24
0
8
% T
% Val:
0
0
0
0
0
93
0
0
0
8
0
0
0
70
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
70
24
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _