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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIP4K2B
All Species:
33.94
Human Site:
S227
Identified Species:
67.88
UniProt:
P78356
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78356
NP_003550.1
416
47378
S227
S
T
V
A
R
E
A
S
D
K
E
K
A
K
D
Chimpanzee
Pan troglodytes
XP_001172818
377
42820
A223
D
L
K
G
S
T
V
A
R
E
A
S
D
K
E
Rhesus Macaque
Macaca mulatta
XP_001099389
382
43672
D225
G
Q
K
I
Y
I
D
D
N
N
K
K
V
F
L
Dog
Lupus familis
XP_548154
416
47327
S227
S
T
V
A
R
E
A
S
D
K
E
K
A
K
D
Cat
Felis silvestris
Mouse
Mus musculus
Q80XI4
416
47300
S227
S
T
V
A
R
E
A
S
D
K
E
K
A
K
D
Rat
Rattus norvegicus
O88377
416
47245
S227
S
T
V
A
R
E
A
S
D
K
E
K
A
K
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510625
479
54696
S291
S
T
V
A
R
E
A
S
Y
K
E
K
A
K
E
Chicken
Gallus gallus
Q5F356
405
46073
S221
S
T
V
A
R
E
A
S
D
K
E
K
A
K
E
Frog
Xenopus laevis
Q5PQ01
419
47633
S233
S
L
V
S
R
E
A
S
D
K
E
K
V
K
E
Zebra Danio
Brachydanio rerio
Q6IQE1
416
47361
S225
S
L
V
D
R
E
A
S
D
K
E
K
V
K
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_392797
416
47916
S220
S
T
V
D
R
E
A
S
D
K
E
K
E
K
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RY89
769
87385
E537
S
T
Q
G
R
Y
T
E
K
N
K
I
G
E
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.5
69.4
99.2
N.A.
99
98.3
N.A.
62
77.6
67.7
65.3
N.A.
N.A.
58.6
N.A.
N.A.
Protein Similarity:
100
89.4
80
99.7
N.A.
99.7
99
N.A.
73
88.9
82
80.5
N.A.
N.A.
74
N.A.
N.A.
P-Site Identity:
100
6.6
6.6
100
N.A.
100
100
N.A.
86.6
93.3
73.3
73.3
N.A.
N.A.
86.6
N.A.
N.A.
P-Site Similarity:
100
26.6
20
100
N.A.
100
100
N.A.
93.3
100
86.6
80
N.A.
N.A.
86.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
32.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
50
0
0
75
9
0
0
9
0
50
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
17
0
0
9
9
67
0
0
0
9
0
42
% D
% Glu:
0
0
0
0
0
75
0
9
0
9
75
0
9
9
42
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% F
% Gly:
9
0
0
17
0
0
0
0
0
0
0
0
9
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
9
0
9
0
0
0
0
0
9
0
0
0
% I
% Lys:
0
0
17
0
0
0
0
0
9
75
17
84
0
84
9
% K
% Leu:
0
25
0
0
0
0
0
0
0
0
0
0
0
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
9
17
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
9
9
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
84
0
0
0
9
0
0
0
0
0
0
% R
% Ser:
84
0
0
9
9
0
0
75
0
0
0
9
0
0
0
% S
% Thr:
0
67
0
0
0
9
9
0
0
0
0
0
0
0
0
% T
% Val:
0
0
75
0
0
0
9
0
0
0
0
0
25
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
9
9
0
0
9
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _