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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIP4K2B
All Species:
33.94
Human Site:
T237
Identified Species:
67.88
UniProt:
P78356
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78356
NP_003550.1
416
47378
T237
E
K
A
K
D
L
P
T
F
K
D
N
D
F
L
Chimpanzee
Pan troglodytes
XP_001172818
377
42820
K233
A
S
D
K
E
K
A
K
D
L
P
T
F
K
D
Rhesus Macaque
Macaca mulatta
XP_001099389
382
43672
L235
K
K
V
F
L
E
K
L
K
K
D
V
E
F
L
Dog
Lupus familis
XP_548154
416
47327
T237
E
K
A
K
D
L
P
T
F
K
D
N
D
F
L
Cat
Felis silvestris
Mouse
Mus musculus
Q80XI4
416
47300
T237
E
K
A
K
D
L
P
T
F
K
D
N
D
F
L
Rat
Rattus norvegicus
O88377
416
47245
T237
E
K
A
K
D
L
P
T
F
K
D
N
D
F
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510625
479
54696
T301
E
K
A
K
E
L
P
T
L
K
D
N
D
F
I
Chicken
Gallus gallus
Q5F356
405
46073
T231
E
K
A
K
E
L
P
T
F
K
D
N
D
F
I
Frog
Xenopus laevis
Q5PQ01
419
47633
T243
E
K
V
K
E
L
P
T
L
K
D
M
D
F
L
Zebra Danio
Brachydanio rerio
Q6IQE1
416
47361
T235
E
K
V
K
E
L
P
T
F
K
D
M
D
F
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_392797
416
47916
T230
E
K
E
K
D
L
P
T
Y
K
D
N
D
F
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RY89
769
87385
L547
K
I
G
E
K
T
T
L
K
D
L
D
L
A
Y
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.5
69.4
99.2
N.A.
99
98.3
N.A.
62
77.6
67.7
65.3
N.A.
N.A.
58.6
N.A.
N.A.
Protein Similarity:
100
89.4
80
99.7
N.A.
99.7
99
N.A.
73
88.9
82
80.5
N.A.
N.A.
74
N.A.
N.A.
P-Site Identity:
100
6.6
33.3
100
N.A.
100
100
N.A.
80
86.6
73.3
73.3
N.A.
N.A.
80
N.A.
N.A.
P-Site Similarity:
100
13.3
46.6
100
N.A.
100
100
N.A.
93.3
100
80
80
N.A.
N.A.
93.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
32.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
50
0
0
0
9
0
0
0
0
0
0
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
9
0
42
0
0
0
9
9
84
9
75
0
9
% D
% Glu:
75
0
9
9
42
9
0
0
0
0
0
0
9
0
0
% E
% Phe:
0
0
0
9
0
0
0
0
50
0
0
0
9
84
0
% F
% Gly:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
17
% I
% Lys:
17
84
0
84
9
9
9
9
17
84
0
0
0
9
0
% K
% Leu:
0
0
0
0
9
75
0
17
17
9
9
0
9
0
50
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
17
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
59
0
0
0
% N
% Pro:
0
0
0
0
0
0
75
0
0
0
9
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% R
% Ser:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
9
9
75
0
0
0
9
0
0
0
% T
% Val:
0
0
25
0
0
0
0
0
0
0
0
9
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _