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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIP4K2B
All Species:
39.39
Human Site:
Y374
Identified Species:
78.79
UniProt:
P78356
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78356
NP_003550.1
416
47378
Y374
I
I
D
I
L
T
P
Y
D
T
K
K
K
A
A
Chimpanzee
Pan troglodytes
XP_001172818
377
42820
F336
N
L
L
S
F
P
R
F
F
G
P
G
E
F
D
Rhesus Macaque
Macaca mulatta
XP_001099389
382
43672
Y340
I
I
D
I
L
T
H
Y
D
A
K
K
K
A
A
Dog
Lupus familis
XP_548154
416
47327
Y374
I
I
D
I
L
T
P
Y
D
A
K
K
K
A
A
Cat
Felis silvestris
Mouse
Mus musculus
Q80XI4
416
47300
Y374
I
I
D
I
L
T
P
Y
D
A
K
K
K
A
A
Rat
Rattus norvegicus
O88377
416
47245
Y374
I
I
D
I
L
T
P
Y
D
A
K
K
K
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510625
479
54696
Y433
I
I
D
I
L
T
H
Y
D
A
K
K
K
A
A
Chicken
Gallus gallus
Q5F356
405
46073
Y363
I
I
D
I
L
T
H
Y
D
A
K
K
K
A
A
Frog
Xenopus laevis
Q5PQ01
419
47633
Y377
L
I
D
I
L
T
H
Y
D
A
K
K
K
A
A
Zebra Danio
Brachydanio rerio
Q6IQE1
416
47361
Y374
L
I
D
V
L
T
Q
Y
D
T
K
K
K
A
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_392797
416
47916
Y373
I
I
D
V
L
T
H
Y
G
V
R
K
Q
A
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RY89
769
87385
Y725
I
I
D
I
L
Q
E
Y
N
M
K
K
K
V
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.5
69.4
99.2
N.A.
99
98.3
N.A.
62
77.6
67.7
65.3
N.A.
N.A.
58.6
N.A.
N.A.
Protein Similarity:
100
89.4
80
99.7
N.A.
99.7
99
N.A.
73
88.9
82
80.5
N.A.
N.A.
74
N.A.
N.A.
P-Site Identity:
100
0
86.6
93.3
N.A.
93.3
93.3
N.A.
86.6
86.6
80
80
N.A.
N.A.
60
N.A.
N.A.
P-Site Similarity:
100
20
86.6
93.3
N.A.
93.3
93.3
N.A.
86.6
86.6
86.6
93.3
N.A.
N.A.
80
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
32.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
60
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
59
0
0
0
84
84
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
92
0
0
0
0
0
75
0
0
0
0
0
9
% D
% Glu:
0
0
0
0
0
0
9
0
0
0
0
0
9
0
9
% E
% Phe:
0
0
0
0
9
0
0
9
9
0
0
0
0
9
0
% F
% Gly:
0
0
0
0
0
0
0
0
9
9
0
9
0
0
0
% G
% His:
0
0
0
0
0
0
42
0
0
0
0
0
0
0
0
% H
% Ile:
75
92
0
75
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
84
92
84
0
0
% K
% Leu:
17
9
9
0
92
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% M
% Asn:
9
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
9
34
0
0
0
9
0
0
0
0
% P
% Gln:
0
0
0
0
0
9
9
0
0
0
0
0
9
0
0
% Q
% Arg:
0
0
0
0
0
0
9
0
0
0
9
0
0
0
0
% R
% Ser:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
84
0
0
0
17
0
0
0
0
0
% T
% Val:
0
0
0
17
0
0
0
0
0
9
0
0
0
9
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
92
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _