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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCA4 All Species: 17.88
Human Site: Y2203 Identified Species: 35.76
UniProt: P78363 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P78363 NP_000341.2 2273 255944 Y2203 S V Q R E R H Y N M L Q F Q V
Chimpanzee Pan troglodytes XP_001152577 2346 264166 Y2276 S V Q R E R H Y N M L Q F Q V
Rhesus Macaque Macaca mulatta XP_001093459 2148 234326 L2057 R E A H G C R L R F Q L P P G
Dog Lupus familis XP_538773 2261 253895 M2175 L K E K H R N M L Q Y Q L P S
Cat Felis silvestris
Mouse Mus musculus O35600 2310 260191 H2202 S V Q R E R H H S M L Q F Q V
Rat Rattus norvegicus Q7TNJ2 2170 237702 L2080 R E V H G S R L R F Q L P P G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516009 2266 254238 M2180 L K E K H R N M L Q Y Q L P S
Chicken Gallus gallus XP_422330 2276 256293 Y2196 S L Q R E K H Y N M L Q Y Q I
Frog Xenopus laevis NP_001089022 2363 267334 Y2282 S V Q R E K H Y N M L Q Y Q I
Zebra Danio Brachydanio rerio XP_683123 2330 265308 Y2248 C I Q R E K H Y N T L Q Y E I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34358 1704 191394 L1635 T T S T N K T L N L K W Q I P
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84M24 1882 209045 S1813 E K F S A L D S F I Q S S F P
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.1 45.2 51 N.A. 87 45.4 N.A. 50.9 71.6 66.6 63.4 N.A. N.A. N.A. 23.7 N.A.
Protein Similarity: 100 96.3 62 67.9 N.A. 92.8 63.5 N.A. 67.7 83.4 79.7 76.8 N.A. N.A. N.A. 42.1 N.A.
P-Site Identity: 100 100 0 13.3 N.A. 86.6 0 N.A. 13.3 73.3 80 53.3 N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 100 100 0 33.3 N.A. 100 0 N.A. 33.3 100 100 86.6 N.A. N.A. N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 21.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 37.7 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 9 0 9 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 9 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % D
% Glu: 9 17 17 0 50 0 0 0 0 0 0 0 0 9 0 % E
% Phe: 0 0 9 0 0 0 0 0 9 17 0 0 25 9 0 % F
% Gly: 0 0 0 0 17 0 0 0 0 0 0 0 0 0 17 % G
% His: 0 0 0 17 17 0 50 9 0 0 0 0 0 0 0 % H
% Ile: 0 9 0 0 0 0 0 0 0 9 0 0 0 9 25 % I
% Lys: 0 25 0 17 0 34 0 0 0 0 9 0 0 0 0 % K
% Leu: 17 9 0 0 0 9 0 25 17 9 50 17 17 0 0 % L
% Met: 0 0 0 0 0 0 0 17 0 42 0 0 0 0 0 % M
% Asn: 0 0 0 0 9 0 17 0 50 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 17 34 17 % P
% Gln: 0 0 50 0 0 0 0 0 0 17 25 67 9 42 0 % Q
% Arg: 17 0 0 50 0 42 17 0 17 0 0 0 0 0 0 % R
% Ser: 42 0 9 9 0 9 0 9 9 0 0 9 9 0 17 % S
% Thr: 9 9 0 9 0 0 9 0 0 9 0 0 0 0 0 % T
% Val: 0 34 9 0 0 0 0 0 0 0 0 0 0 0 25 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 42 0 0 17 0 25 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _