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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX6-1
All Species:
16.97
Human Site:
S125
Identified Species:
33.94
UniProt:
P78426
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78426
NP_006159
367
37849
S125
A
S
P
S
G
S
S
S
S
S
S
S
S
A
S
Chimpanzee
Pan troglodytes
XP_521638
440
46674
G157
H
S
R
P
T
F
S
G
Q
Q
I
F
A
L
E
Rhesus Macaque
Macaca mulatta
XP_001104458
366
37790
S125
A
S
P
S
G
S
S
S
S
S
S
S
S
A
S
Dog
Lupus familis
XP_544960
366
37787
S125
A
S
P
S
G
S
S
S
S
S
S
S
S
S
T
Cat
Felis silvestris
Mouse
Mus musculus
Q99MA9
365
37687
S124
S
A
S
P
S
G
S
S
S
S
S
S
S
S
A
Rat
Rattus norvegicus
O35762
365
37671
S124
S
A
S
P
S
G
S
S
S
S
S
S
S
S
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510049
265
28997
A24
A
Q
F
S
E
M
K
A
P
M
C
Q
Y
A
M
Chicken
Gallus gallus
O93367
297
32351
D54
P
P
P
P
R
G
P
D
G
A
A
F
L
G
G
Frog
Xenopus laevis
A5YC49
254
27880
S13
P
G
A
F
L
L
P
S
Y
S
E
M
K
S
S
Zebra Danio
Brachydanio rerio
Q504H8
297
33069
E54
F
S
L
S
Q
V
G
E
I
N
F
P
R
F
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P56407
147
17231
Sea Urchin
Strong. purpuratus
Q26656
405
44721
A142
L
A
A
H
R
A
A
A
L
H
I
P
S
A
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
22.5
99.1
97.8
N.A.
96.4
96.4
N.A.
39.5
25.8
34.5
22.3
N.A.
N.A.
N.A.
22.3
22.7
Protein Similarity:
100
34.5
99.4
97.8
N.A.
97.2
97
N.A.
48.7
35.1
44.4
36.5
N.A.
N.A.
N.A.
29.7
36
P-Site Identity:
100
13.3
100
86.6
N.A.
46.6
46.6
N.A.
20
6.6
20
13.3
N.A.
N.A.
N.A.
0
13.3
P-Site Similarity:
100
20
100
100
N.A.
73.3
73.3
N.A.
26.6
20
26.6
20
N.A.
N.A.
N.A.
0
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
34
25
17
0
0
9
9
17
0
9
9
0
9
34
25
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
9
0
0
9
0
0
9
0
0
0
17
% E
% Phe:
9
0
9
9
0
9
0
0
0
0
9
17
0
9
0
% F
% Gly:
0
9
0
0
25
25
9
9
9
0
0
0
0
9
9
% G
% His:
9
0
0
9
0
0
0
0
0
9
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
9
0
17
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
9
0
0
0
0
0
9
0
0
% K
% Leu:
9
0
9
0
9
9
0
0
9
0
0
0
9
9
0
% L
% Met:
0
0
0
0
0
9
0
0
0
9
0
9
0
0
9
% M
% Asn:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% N
% Pro:
17
9
34
34
0
0
17
0
9
0
0
17
0
0
0
% P
% Gln:
0
9
0
0
9
0
0
0
9
9
0
9
0
0
0
% Q
% Arg:
0
0
9
0
17
0
0
0
0
0
0
0
9
0
0
% R
% Ser:
17
42
17
42
17
25
50
50
42
50
42
42
50
34
25
% S
% Thr:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
9
% T
% Val:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
9
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _