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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NKX6-1 All Species: 16.97
Human Site: S125 Identified Species: 33.94
UniProt: P78426 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P78426 NP_006159 367 37849 S125 A S P S G S S S S S S S S A S
Chimpanzee Pan troglodytes XP_521638 440 46674 G157 H S R P T F S G Q Q I F A L E
Rhesus Macaque Macaca mulatta XP_001104458 366 37790 S125 A S P S G S S S S S S S S A S
Dog Lupus familis XP_544960 366 37787 S125 A S P S G S S S S S S S S S T
Cat Felis silvestris
Mouse Mus musculus Q99MA9 365 37687 S124 S A S P S G S S S S S S S S A
Rat Rattus norvegicus O35762 365 37671 S124 S A S P S G S S S S S S S S A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510049 265 28997 A24 A Q F S E M K A P M C Q Y A M
Chicken Gallus gallus O93367 297 32351 D54 P P P P R G P D G A A F L G G
Frog Xenopus laevis A5YC49 254 27880 S13 P G A F L L P S Y S E M K S S
Zebra Danio Brachydanio rerio Q504H8 297 33069 E54 F S L S Q V G E I N F P R F E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P56407 147 17231
Sea Urchin Strong. purpuratus Q26656 405 44721 A142 L A A H R A A A L H I P S A A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 22.5 99.1 97.8 N.A. 96.4 96.4 N.A. 39.5 25.8 34.5 22.3 N.A. N.A. N.A. 22.3 22.7
Protein Similarity: 100 34.5 99.4 97.8 N.A. 97.2 97 N.A. 48.7 35.1 44.4 36.5 N.A. N.A. N.A. 29.7 36
P-Site Identity: 100 13.3 100 86.6 N.A. 46.6 46.6 N.A. 20 6.6 20 13.3 N.A. N.A. N.A. 0 13.3
P-Site Similarity: 100 20 100 100 N.A. 73.3 73.3 N.A. 26.6 20 26.6 20 N.A. N.A. N.A. 0 46.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 34 25 17 0 0 9 9 17 0 9 9 0 9 34 25 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 9 0 0 9 0 0 9 0 0 0 17 % E
% Phe: 9 0 9 9 0 9 0 0 0 0 9 17 0 9 0 % F
% Gly: 0 9 0 0 25 25 9 9 9 0 0 0 0 9 9 % G
% His: 9 0 0 9 0 0 0 0 0 9 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 9 0 17 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 9 0 0 0 0 0 9 0 0 % K
% Leu: 9 0 9 0 9 9 0 0 9 0 0 0 9 9 0 % L
% Met: 0 0 0 0 0 9 0 0 0 9 0 9 0 0 9 % M
% Asn: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % N
% Pro: 17 9 34 34 0 0 17 0 9 0 0 17 0 0 0 % P
% Gln: 0 9 0 0 9 0 0 0 9 9 0 9 0 0 0 % Q
% Arg: 0 0 9 0 17 0 0 0 0 0 0 0 9 0 0 % R
% Ser: 17 42 17 42 17 25 50 50 42 50 42 42 50 34 25 % S
% Thr: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 9 % T
% Val: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 9 0 0 0 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _