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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX6-1
All Species:
8.79
Human Site:
S350
Identified Species:
17.58
UniProt:
P78426
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78426
NP_006159
367
37849
S350
L
K
K
H
K
S
S
S
G
G
G
G
G
L
L
Chimpanzee
Pan troglodytes
XP_521638
440
46674
T382
A
A
G
T
R
P
V
T
S
K
G
P
S
E
R
Rhesus Macaque
Macaca mulatta
XP_001104458
366
37790
S350
L
K
K
H
K
S
S
S
G
G
G
G
L
L
L
Dog
Lupus familis
XP_544960
366
37787
G350
L
L
K
K
H
K
S
G
G
G
G
G
L
L
L
Cat
Felis silvestris
Mouse
Mus musculus
Q99MA9
365
37687
S349
Q
L
L
K
K
H
K
S
S
G
G
S
L
L
L
Rat
Rattus norvegicus
O35762
365
37671
S349
Q
L
L
K
K
H
K
S
S
G
G
S
L
L
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510049
265
28997
R249
E
K
I
R
L
L
L
R
K
H
R
A
A
F
S
Chicken
Gallus gallus
O93367
297
32351
N279
S
S
L
F
A
L
Q
N
L
Q
P
W
E
E
E
Frog
Xenopus laevis
A5YC49
254
27880
R238
E
K
I
R
L
L
L
R
K
H
R
A
A
F
S
Zebra Danio
Brachydanio rerio
Q504H8
297
33069
H279
Q
P
L
L
T
F
P
H
P
V
Y
Y
S
H
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P56407
147
17231
E131
K
W
K
K
I
E
S
E
K
E
R
S
G
E
I
Sea Urchin
Strong. purpuratus
Q26656
405
44721
H367
P
T
T
G
S
S
L
H
S
P
N
I
L
P
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
22.5
99.1
97.8
N.A.
96.4
96.4
N.A.
39.5
25.8
34.5
22.3
N.A.
N.A.
N.A.
22.3
22.7
Protein Similarity:
100
34.5
99.4
97.8
N.A.
97.2
97
N.A.
48.7
35.1
44.4
36.5
N.A.
N.A.
N.A.
29.7
36
P-Site Identity:
100
6.6
93.3
60
N.A.
40
40
N.A.
6.6
0
6.6
0
N.A.
N.A.
N.A.
20
6.6
P-Site Similarity:
100
20
93.3
60
N.A.
40
40
N.A.
6.6
6.6
6.6
0
N.A.
N.A.
N.A.
26.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
0
0
9
0
0
0
0
0
0
17
17
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
17
0
0
0
0
9
0
9
0
9
0
0
9
25
9
% E
% Phe:
0
0
0
9
0
9
0
0
0
0
0
0
0
17
9
% F
% Gly:
0
0
9
9
0
0
0
9
25
42
50
25
17
0
0
% G
% His:
0
0
0
17
9
17
0
17
0
17
0
0
0
9
0
% H
% Ile:
0
0
17
0
9
0
0
0
0
0
0
9
0
0
9
% I
% Lys:
9
34
34
34
34
9
17
0
25
9
0
0
0
0
0
% K
% Leu:
25
25
34
9
17
25
25
0
9
0
0
0
42
42
42
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
9
0
0
9
0
0
0
0
% N
% Pro:
9
9
0
0
0
9
9
0
9
9
9
9
0
9
9
% P
% Gln:
25
0
0
0
0
0
9
0
0
9
0
0
0
0
0
% Q
% Arg:
0
0
0
17
9
0
0
17
0
0
25
0
0
0
9
% R
% Ser:
9
9
0
0
9
25
34
34
34
0
0
25
17
0
17
% S
% Thr:
0
9
9
9
9
0
0
9
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
9
0
0
9
0
0
0
0
0
% V
% Trp:
0
9
0
0
0
0
0
0
0
0
0
9
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
9
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _