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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX6-1
All Species:
17.58
Human Site:
S54
Identified Species:
35.15
UniProt:
P78426
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78426
NP_006159
367
37849
S54
P
P
S
S
S
S
S
S
S
S
S
S
S
P
S
Chimpanzee
Pan troglodytes
XP_521638
440
46674
A86
L
P
R
L
N
G
L
A
S
S
A
G
V
Y
F
Rhesus Macaque
Macaca mulatta
XP_001104458
366
37790
S54
P
P
S
S
S
S
S
S
S
S
S
S
S
P
S
Dog
Lupus familis
XP_544960
366
37787
S54
P
P
S
S
S
S
S
S
S
S
S
S
S
P
S
Cat
Felis silvestris
Mouse
Mus musculus
Q99MA9
365
37687
S53
G
P
P
S
S
S
S
S
S
S
S
S
S
S
P
Rat
Rattus norvegicus
O35762
365
37671
S53
G
P
P
S
S
S
S
S
S
S
S
S
S
S
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510049
265
28997
Chicken
Gallus gallus
O93367
297
32351
Frog
Xenopus laevis
A5YC49
254
27880
Zebra Danio
Brachydanio rerio
Q504H8
297
33069
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P56407
147
17231
Sea Urchin
Strong. purpuratus
Q26656
405
44721
T71
P
P
P
S
Q
P
R
T
K
G
F
S
I
E
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
22.5
99.1
97.8
N.A.
96.4
96.4
N.A.
39.5
25.8
34.5
22.3
N.A.
N.A.
N.A.
22.3
22.7
Protein Similarity:
100
34.5
99.4
97.8
N.A.
97.2
97
N.A.
48.7
35.1
44.4
36.5
N.A.
N.A.
N.A.
29.7
36
P-Site Identity:
100
20
100
100
N.A.
73.3
73.3
N.A.
0
0
0
0
N.A.
N.A.
N.A.
0
33.3
P-Site Similarity:
100
40
100
100
N.A.
73.3
73.3
N.A.
0
0
0
0
N.A.
N.A.
N.A.
0
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
9
0
0
9
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
9
% F
% Gly:
17
0
0
0
0
9
0
0
0
9
0
9
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% K
% Leu:
9
0
0
9
0
0
9
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
34
59
25
0
0
9
0
0
0
0
0
0
0
25
17
% P
% Gln:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
9
0
0
0
9
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
25
50
42
42
42
42
50
50
42
50
42
17
34
% S
% Thr:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _