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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX6-1
All Species:
7.88
Human Site:
T254
Identified Species:
15.76
UniProt:
P78426
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78426
NP_006159
367
37849
T254
Q
I
F
A
L
E
K
T
F
E
Q
T
K
Y
L
Chimpanzee
Pan troglodytes
XP_521638
440
46674
X286
X
X
K
X
X
N
G
X
P
X
E
P
X
X
R
Rhesus Macaque
Macaca mulatta
XP_001104458
366
37790
T254
Q
I
F
A
L
E
K
T
F
E
Q
T
K
Y
L
Dog
Lupus familis
XP_544960
366
37787
K254
Q
Q
I
F
A
L
E
K
T
F
E
Q
T
K
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q99MA9
365
37687
E253
G
Q
Q
I
F
A
L
E
K
T
F
E
Q
T
K
Rat
Rattus norvegicus
O35762
365
37671
E253
G
Q
Q
I
F
A
L
E
K
T
F
E
Q
T
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510049
265
28997
A153
F
T
G
H
Q
I
F
A
L
E
K
T
F
E
Q
Chicken
Gallus gallus
O93367
297
32351
Q183
R
T
S
F
S
R
V
Q
I
C
E
L
E
K
R
Frog
Xenopus laevis
A5YC49
254
27880
G142
H
T
R
P
T
F
T
G
H
Q
I
F
A
L
E
Zebra Danio
Brachydanio rerio
Q504H8
297
33069
F183
V
F
S
R
S
Q
V
F
Q
L
E
S
T
F
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P56407
147
17231
L35
S
H
L
I
K
D
I
L
D
L
P
T
V
N
G
Sea Urchin
Strong. purpuratus
Q26656
405
44721
T271
Q
V
F
Q
L
E
S
T
F
E
V
K
R
Y
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
22.5
99.1
97.8
N.A.
96.4
96.4
N.A.
39.5
25.8
34.5
22.3
N.A.
N.A.
N.A.
22.3
22.7
Protein Similarity:
100
34.5
99.4
97.8
N.A.
97.2
97
N.A.
48.7
35.1
44.4
36.5
N.A.
N.A.
N.A.
29.7
36
P-Site Identity:
100
0
100
6.6
N.A.
0
0
N.A.
13.3
0
0
0
N.A.
N.A.
N.A.
6.6
60
P-Site Similarity:
100
6.6
100
20
N.A.
6.6
6.6
N.A.
20
20
6.6
26.6
N.A.
N.A.
N.A.
13.3
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
17
9
17
0
9
0
0
0
0
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
9
0
0
9
0
0
0
0
0
9
% D
% Glu:
0
0
0
0
0
25
9
17
0
34
34
17
9
9
9
% E
% Phe:
9
9
25
17
17
9
9
9
25
9
17
9
9
9
0
% F
% Gly:
17
0
9
0
0
0
9
9
0
0
0
0
0
0
9
% G
% His:
9
9
0
9
0
0
0
0
9
0
0
0
0
0
0
% H
% Ile:
0
17
9
25
0
9
9
0
9
0
9
0
0
0
0
% I
% Lys:
0
0
9
0
9
0
17
9
17
0
9
9
17
17
17
% K
% Leu:
0
0
9
0
25
9
17
9
9
17
0
9
0
9
25
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
9
0
0
0
0
0
0
0
9
0
% N
% Pro:
0
0
0
9
0
0
0
0
9
0
9
9
0
0
0
% P
% Gln:
34
25
17
9
9
9
0
9
9
9
17
9
17
0
9
% Q
% Arg:
9
0
9
9
0
9
0
0
0
0
0
0
9
0
17
% R
% Ser:
9
0
17
0
17
0
9
0
0
0
0
9
0
0
0
% S
% Thr:
0
25
0
0
9
0
9
25
9
17
0
34
17
17
0
% T
% Val:
9
9
0
0
0
0
17
0
0
0
9
0
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
25
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _