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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADAM17
All Species:
24.55
Human Site:
S169
Identified Species:
45
UniProt:
P78536
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78536
NP_003174.3
824
93021
S169
K
R
M
L
V
Y
K
S
E
D
I
K
N
V
S
Chimpanzee
Pan troglodytes
XP_001154844
807
90985
S169
K
R
M
L
V
Y
K
S
E
D
I
K
N
V
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532870
787
87680
N164
K
P
G
E
R
H
Y
N
M
A
K
S
Y
P
N
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0F8
827
93055
S169
K
R
M
L
V
Y
K
S
E
D
I
K
D
F
S
Rat
Rattus norvegicus
Q9Z1K9
827
92999
S169
K
R
M
L
V
Y
K
S
E
D
I
K
D
F
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516484
430
47905
Chicken
Gallus gallus
NP_001008682
829
93588
S170
E
R
L
L
V
Y
R
S
E
D
I
K
D
F
S
Frog
Xenopus laevis
Q8JIY1
749
84049
E157
F
H
S
V
M
Y
H
E
D
D
I
K
Y
P
H
Zebra Danio
Brachydanio rerio
XP_689147
838
93831
S167
S
R
L
L
V
Y
R
S
E
D
I
R
N
V
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VAC5
732
83062
Y144
I
H
L
P
E
E
T
Y
H
I
E
P
S
W
R
Honey Bee
Apis mellifera
XP_623993
716
82155
I128
I
S
D
E
T
F
H
I
E
P
S
W
R
H
L
Nematode Worm
Caenorhab. elegans
NP_509318
686
77280
T98
R
A
G
R
A
V
L
T
Q
L
E
E
N
V
Y
Sea Urchin
Strong. purpuratus
XP_790625
763
85522
T161
S
S
D
I
K
Q
N
T
T
A
S
F
C
P
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
N.A.
68.6
N.A.
91.9
92.1
N.A.
48
76.4
28.5
61.4
N.A.
37.3
37.2
26.3
33.2
Protein Similarity:
100
97.9
N.A.
72
N.A.
96.3
96.3
N.A.
50
87.2
44.7
74.8
N.A.
54.2
53
43.4
51.5
P-Site Identity:
100
100
N.A.
6.6
N.A.
86.6
86.6
N.A.
0
66.6
26.6
73.3
N.A.
0
6.6
13.3
0
P-Site Similarity:
100
100
N.A.
26.6
N.A.
93.3
93.3
N.A.
0
93.3
46.6
93.3
N.A.
13.3
13.3
40
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
8
0
0
0
0
16
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% C
% Asp:
0
0
16
0
0
0
0
0
8
54
0
0
24
0
0
% D
% Glu:
8
0
0
16
8
8
0
8
54
0
16
8
0
0
0
% E
% Phe:
8
0
0
0
0
8
0
0
0
0
0
8
0
24
0
% F
% Gly:
0
0
16
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
16
0
0
0
8
16
0
8
0
0
0
0
8
16
% H
% Ile:
16
0
0
8
0
0
0
8
0
8
54
0
0
0
0
% I
% Lys:
39
0
0
0
8
0
31
0
0
0
8
47
0
0
0
% K
% Leu:
0
0
24
47
0
0
8
0
0
8
0
0
0
0
8
% L
% Met:
0
0
31
0
8
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
8
0
0
0
0
31
0
8
% N
% Pro:
0
8
0
8
0
0
0
0
0
8
0
8
0
24
0
% P
% Gln:
0
0
0
0
0
8
0
0
8
0
0
0
0
0
0
% Q
% Arg:
8
47
0
8
8
0
16
0
0
0
0
8
8
0
8
% R
% Ser:
16
16
8
0
0
0
0
47
0
0
16
8
8
0
47
% S
% Thr:
0
0
0
0
8
0
8
16
8
0
0
0
0
0
0
% T
% Val:
0
0
0
8
47
8
0
0
0
0
0
0
0
31
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
8
0
8
0
% W
% Tyr:
0
0
0
0
0
54
8
8
0
0
0
0
16
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _