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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ADAM17 All Species: 11.52
Human Site: S704 Identified Species: 21.11
UniProt: P78536 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P78536 NP_003174.3 824 93021 S704 K L D K Q Y E S L S L F H P S
Chimpanzee Pan troglodytes XP_001154844 807 90985 F687 S L I F W I P F S I L V H C V
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532870 787 87680 S666 V G S V L V F S L I F W I P F
Cat Felis silvestris
Mouse Mus musculus Q9Z0F8 827 93055 S704 K L D K Q Y E S L S L F H H S
Rat Rattus norvegicus Q9Z1K9 827 92999 S704 K L D K Q Y E S L S L F H H S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516484 430 47905 S311 V Q C S D R N S P C C K N C Q
Chicken Gallus gallus NP_001008682 829 93588 L709 Y E E N N K S L F C A S N A E
Frog Xenopus laevis Q8JIY1 749 84049 T626 Y F K G K T I T L Q P G S P C
Zebra Danio Brachydanio rerio XP_689147 838 93831 L701 K L D Q Q Y E L S T K P L F Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VAC5 732 83062 P613 T C F P V E P P D V L P D G T
Honey Bee Apis mellifera XP_623993 716 82155 I597 L N E T C F P I D P Q D I L P
Nematode Worm Caenorhab. elegans NP_509318 686 77280 E567 G K K S C I C E D L E L S C R
Sea Urchin Strong. purpuratus XP_790625 763 85522 V643 W I P C S C L V H Y V D K K R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.9 N.A. 68.6 N.A. 91.9 92.1 N.A. 48 76.4 28.5 61.4 N.A. 37.3 37.2 26.3 33.2
Protein Similarity: 100 97.9 N.A. 72 N.A. 96.3 96.3 N.A. 50 87.2 44.7 74.8 N.A. 54.2 53 43.4 51.5
P-Site Identity: 100 20 N.A. 20 N.A. 93.3 93.3 N.A. 6.6 0 13.3 40 N.A. 6.6 0 0 0
P-Site Similarity: 100 20 N.A. 26.6 N.A. 93.3 93.3 N.A. 13.3 13.3 26.6 53.3 N.A. 13.3 13.3 0 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 8 0 0 8 0 % A
% Cys: 0 8 8 8 16 8 8 0 0 16 8 0 0 24 8 % C
% Asp: 0 0 31 0 8 0 0 0 24 0 0 16 8 0 0 % D
% Glu: 0 8 16 0 0 8 31 8 0 0 8 0 0 0 8 % E
% Phe: 0 8 8 8 0 8 8 8 8 0 8 24 0 8 8 % F
% Gly: 8 8 0 8 0 0 0 0 0 0 0 8 0 8 0 % G
% His: 0 0 0 0 0 0 0 0 8 0 0 0 31 16 0 % H
% Ile: 0 8 8 0 0 16 8 8 0 16 0 0 16 0 0 % I
% Lys: 31 8 16 24 8 8 0 0 0 0 8 8 8 8 0 % K
% Leu: 8 39 0 0 8 0 8 16 39 8 39 8 8 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 0 8 8 0 8 0 0 0 0 0 16 0 0 % N
% Pro: 0 0 8 8 0 0 24 8 8 8 8 16 0 24 8 % P
% Gln: 0 8 0 8 31 0 0 0 0 8 8 0 0 0 8 % Q
% Arg: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 16 % R
% Ser: 8 0 8 16 8 0 8 39 16 24 0 8 16 0 24 % S
% Thr: 8 0 0 8 0 8 0 8 0 8 0 0 0 0 8 % T
% Val: 16 0 0 8 8 8 0 8 0 8 8 8 0 0 8 % V
% Trp: 8 0 0 0 8 0 0 0 0 0 0 8 0 0 0 % W
% Tyr: 16 0 0 0 0 31 0 0 0 8 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _