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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADAM17
All Species:
10.61
Human Site:
S706
Identified Species:
19.44
UniProt:
P78536
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78536
NP_003174.3
824
93021
S706
D
K
Q
Y
E
S
L
S
L
F
H
P
S
N
V
Chimpanzee
Pan troglodytes
XP_001154844
807
90985
I689
I
F
W
I
P
F
S
I
L
V
H
C
V
N
V
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532870
787
87680
I668
S
V
L
V
F
S
L
I
F
W
I
P
F
S
I
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0F8
827
93055
S706
D
K
Q
Y
E
S
L
S
L
F
H
H
S
N
I
Rat
Rattus norvegicus
Q9Z1K9
827
92999
S706
D
K
Q
Y
E
S
L
S
L
F
H
H
S
N
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516484
430
47905
C313
C
S
D
R
N
S
P
C
C
K
N
C
Q
F
E
Chicken
Gallus gallus
NP_001008682
829
93588
C711
E
N
N
K
S
L
F
C
A
S
N
A
E
V
P
Frog
Xenopus laevis
Q8JIY1
749
84049
Q628
K
G
K
T
I
T
L
Q
P
G
S
P
C
N
E
Zebra Danio
Brachydanio rerio
XP_689147
838
93831
T703
D
Q
Q
Y
E
L
S
T
K
P
L
F
Y
P
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VAC5
732
83062
V615
F
P
V
E
P
P
D
V
L
P
D
G
T
P
C
Honey Bee
Apis mellifera
XP_623993
716
82155
P599
E
T
C
F
P
I
D
P
Q
D
I
L
P
D
G
Nematode Worm
Caenorhab. elegans
NP_509318
686
77280
L569
K
S
C
I
C
E
D
L
E
L
S
C
R
L
C
Sea Urchin
Strong. purpuratus
XP_790625
763
85522
Y645
P
C
S
C
L
V
H
Y
V
D
K
K
R
A
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
N.A.
68.6
N.A.
91.9
92.1
N.A.
48
76.4
28.5
61.4
N.A.
37.3
37.2
26.3
33.2
Protein Similarity:
100
97.9
N.A.
72
N.A.
96.3
96.3
N.A.
50
87.2
44.7
74.8
N.A.
54.2
53
43.4
51.5
P-Site Identity:
100
26.6
N.A.
20
N.A.
86.6
86.6
N.A.
6.6
0
20
26.6
N.A.
6.6
0
0
0
P-Site Similarity:
100
26.6
N.A.
40
N.A.
93.3
93.3
N.A.
13.3
13.3
33.3
40
N.A.
13.3
20
0
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
8
0
0
8
0
8
0
% A
% Cys:
8
8
16
8
8
0
0
16
8
0
0
24
8
0
16
% C
% Asp:
31
0
8
0
0
0
24
0
0
16
8
0
0
8
0
% D
% Glu:
16
0
0
8
31
8
0
0
8
0
0
0
8
0
16
% E
% Phe:
8
8
0
8
8
8
8
0
8
24
0
8
8
8
0
% F
% Gly:
0
8
0
0
0
0
0
0
0
8
0
8
0
0
8
% G
% His:
0
0
0
0
0
0
8
0
0
0
31
16
0
0
0
% H
% Ile:
8
0
0
16
8
8
0
16
0
0
16
0
0
0
24
% I
% Lys:
16
24
8
8
0
0
0
0
8
8
8
8
0
0
0
% K
% Leu:
0
0
8
0
8
16
39
8
39
8
8
8
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
8
0
8
0
0
0
0
0
16
0
0
39
0
% N
% Pro:
8
8
0
0
24
8
8
8
8
16
0
24
8
16
8
% P
% Gln:
0
8
31
0
0
0
0
8
8
0
0
0
8
0
0
% Q
% Arg:
0
0
0
8
0
0
0
0
0
0
0
0
16
0
8
% R
% Ser:
8
16
8
0
8
39
16
24
0
8
16
0
24
8
8
% S
% Thr:
0
8
0
8
0
8
0
8
0
0
0
0
8
0
0
% T
% Val:
0
8
8
8
0
8
0
8
8
8
0
0
8
8
16
% V
% Trp:
0
0
8
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
0
0
0
31
0
0
0
8
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _