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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ADAM17 All Species: 10.91
Human Site: S770 Identified Species: 20
UniProt: P78536 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P78536 NP_003174.3 824 93021 S770 Q E D P S T D S H M D E D G F
Chimpanzee Pan troglodytes XP_001154844 807 90985 S753 Q E D P S T D S H M D E D G F
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532870 787 87680 V732 P G R L G L Q V A N C Q D L W
Cat Felis silvestris
Mouse Mus musculus Q9Z0F8 827 93055 S770 D T I Q E D P S T D S H V D D
Rat Rattus norvegicus Q9Z1K9 827 92999 S770 D T I Q E D P S T D S H V D D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516484 430 47905 E377 C I P F C E R E K N L Q S C A
Chicken Gallus gallus NP_001008682 829 93588 S775 Q E D P S T D S H I D E D G F
Frog Xenopus laevis Q8JIY1 749 84049 L692 M G I A L I M L M A G F I K I
Zebra Danio Brachydanio rerio XP_689147 838 93831 T767 P A P I Q T P T P C P L P N I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VAC5 732 83062 S679 A V F W I P I S C V I S Y F D
Honey Bee Apis mellifera XP_623993 716 82155 I663 I I T A I V W I P T S C V I S
Nematode Worm Caenorhab. elegans NP_509318 686 77280 E633 Q T T G G V L E F I K T H I V
Sea Urchin Strong. purpuratus XP_790625 763 85522 G709 K T N F M L C G A I D R I H Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.9 N.A. 68.6 N.A. 91.9 92.1 N.A. 48 76.4 28.5 61.4 N.A. 37.3 37.2 26.3 33.2
Protein Similarity: 100 97.9 N.A. 72 N.A. 96.3 96.3 N.A. 50 87.2 44.7 74.8 N.A. 54.2 53 43.4 51.5
P-Site Identity: 100 100 N.A. 6.6 N.A. 6.6 6.6 N.A. 0 93.3 0 6.6 N.A. 6.6 0 6.6 6.6
P-Site Similarity: 100 100 N.A. 20 N.A. 6.6 6.6 N.A. 6.6 100 0 13.3 N.A. 13.3 0 13.3 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 0 16 0 0 0 0 16 8 0 0 0 0 8 % A
% Cys: 8 0 0 0 8 0 8 0 8 8 8 8 0 8 0 % C
% Asp: 16 0 24 0 0 16 24 0 0 16 31 0 31 16 24 % D
% Glu: 0 24 0 0 16 8 0 16 0 0 0 24 0 0 0 % E
% Phe: 0 0 8 16 0 0 0 0 8 0 0 8 0 8 24 % F
% Gly: 0 16 0 8 16 0 0 8 0 0 8 0 0 24 0 % G
% His: 0 0 0 0 0 0 0 0 24 0 0 16 8 8 0 % H
% Ile: 8 16 24 8 16 8 8 8 0 24 8 0 16 16 16 % I
% Lys: 8 0 0 0 0 0 0 0 8 0 8 0 0 8 0 % K
% Leu: 0 0 0 8 8 16 8 8 0 0 8 8 0 8 0 % L
% Met: 8 0 0 0 8 0 8 0 8 16 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 0 0 0 0 16 0 0 0 8 0 % N
% Pro: 16 0 16 24 0 8 24 0 16 0 8 0 8 0 0 % P
% Gln: 31 0 0 16 8 0 8 0 0 0 0 16 0 0 0 % Q
% Arg: 0 0 8 0 0 0 8 0 0 0 0 8 0 0 0 % R
% Ser: 0 0 0 0 24 0 0 47 0 0 24 8 8 0 8 % S
% Thr: 0 31 16 0 0 31 0 8 16 8 0 8 0 0 0 % T
% Val: 0 8 0 0 0 16 0 8 0 8 0 0 24 0 8 % V
% Trp: 0 0 0 8 0 0 8 0 0 0 0 0 0 0 8 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _