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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADAM17
All Species:
13.03
Human Site:
T735
Identified Species:
23.89
UniProt:
P78536
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78536
NP_003174.3
824
93021
T735
K
P
F
P
A
P
Q
T
P
G
R
L
Q
P
A
Chimpanzee
Pan troglodytes
XP_001154844
807
90985
T718
K
P
F
P
A
P
Q
T
P
G
R
L
Q
P
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532870
787
87680
S697
S
L
S
L
F
H
P
S
V
S
T
W
E
T
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0F8
827
93055
T735
K
P
F
P
A
P
Q
T
P
G
R
L
Q
A
L
Rat
Rattus norvegicus
Q9Z1K9
827
92999
T735
K
P
F
P
A
P
Q
T
P
G
R
L
Q
A
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516484
430
47905
G342
K
G
Q
S
Y
C
T
G
N
S
S
E
C
P
P
Chicken
Gallus gallus
NP_001008682
829
93588
R740
P
A
A
Q
P
T
S
R
H
Q
P
L
Q
P
I
Frog
Xenopus laevis
Q8JIY1
749
84049
R657
D
A
D
G
P
L
A
R
L
K
K
A
I
F
N
Zebra Danio
Brachydanio rerio
XP_689147
838
93831
A732
I
F
K
P
P
S
S
A
G
S
S
V
V
P
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VAC5
732
83062
W644
Q
D
V
V
E
R
F
W
D
I
I
E
E
I
N
Honey Bee
Apis mellifera
XP_623993
716
82155
E628
K
T
I
Q
D
V
V
E
R
F
W
D
I
I
E
Nematode Worm
Caenorhab. elegans
NP_509318
686
77280
R598
V
Y
L
R
D
G
V
R
C
S
K
G
S
C
R
Sea Urchin
Strong. purpuratus
XP_790625
763
85522
D674
G
F
S
Q
V
Y
V
D
N
L
M
V
T
D
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
N.A.
68.6
N.A.
91.9
92.1
N.A.
48
76.4
28.5
61.4
N.A.
37.3
37.2
26.3
33.2
Protein Similarity:
100
97.9
N.A.
72
N.A.
96.3
96.3
N.A.
50
87.2
44.7
74.8
N.A.
54.2
53
43.4
51.5
P-Site Identity:
100
100
N.A.
0
N.A.
86.6
86.6
N.A.
13.3
20
0
13.3
N.A.
0
6.6
0
0
P-Site Similarity:
100
100
N.A.
13.3
N.A.
86.6
86.6
N.A.
13.3
20
6.6
20
N.A.
13.3
6.6
6.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
8
0
31
0
8
8
0
0
0
8
0
16
16
% A
% Cys:
0
0
0
0
0
8
0
0
8
0
0
0
8
8
0
% C
% Asp:
8
8
8
0
16
0
0
8
8
0
0
8
0
8
0
% D
% Glu:
0
0
0
0
8
0
0
8
0
0
0
16
16
0
8
% E
% Phe:
0
16
31
0
8
0
8
0
0
8
0
0
0
8
0
% F
% Gly:
8
8
0
8
0
8
0
8
8
31
0
8
0
0
0
% G
% His:
0
0
0
0
0
8
0
0
8
0
0
0
0
0
0
% H
% Ile:
8
0
8
0
0
0
0
0
0
8
8
0
16
16
8
% I
% Lys:
47
0
8
0
0
0
0
0
0
8
16
0
0
0
0
% K
% Leu:
0
8
8
8
0
8
0
0
8
8
0
39
0
0
16
% L
% Met:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
16
0
0
0
0
0
16
% N
% Pro:
8
31
0
39
24
31
8
0
31
0
8
0
0
39
8
% P
% Gln:
8
0
8
24
0
0
31
0
0
8
0
0
39
0
8
% Q
% Arg:
0
0
0
8
0
8
0
24
8
0
31
0
0
0
16
% R
% Ser:
8
0
16
8
0
8
16
8
0
31
16
0
8
0
0
% S
% Thr:
0
8
0
0
0
8
8
31
0
0
8
0
8
8
0
% T
% Val:
8
0
8
8
8
8
24
0
8
0
0
16
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
8
0
0
8
8
0
0
0
% W
% Tyr:
0
8
0
0
8
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _