Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ADAM17 All Species: 10.3
Human Site: T796 Identified Species: 18.89
UniProt: P78536 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P78536 NP_003174.3 824 93021 T796 A K S F E D L T D H P V T R S
Chimpanzee Pan troglodytes XP_001154844 807 90985 T779 A K S F E D L T D H P V T R S
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532870 787 87680 P758 S V G A V M G P G A D R L L A
Cat Felis silvestris
Mouse Mus musculus Q9Z0F8 827 93055 E796 S T A A K S F E D L T D H P V
Rat Rattus norvegicus Q9Z1K9 827 92999 E796 S A A A K S F E D L T D H P V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516484 430 47905 C403 C R D L S G K C A P Y V D A D
Chicken Gallus gallus NP_001008682 829 93588 T801 A K S F E D L T E H P V T R S
Frog Xenopus laevis Q8JIY1 749 84049 P718 L P P P K P L P G T L K R R R
Zebra Danio Brachydanio rerio XP_689147 838 93831 D793 P S Y D S H L D Q V L G E D F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VAC5 732 83062 L705 E W S Q K L D L I H P S D E R
Honey Bee Apis mellifera XP_623993 716 82155 T689 K K W R W K H T D E L I H P D
Nematode Worm Caenorhab. elegans NP_509318 686 77280 K659 V G I Y K I V K Y G E N F T E
Sea Urchin Strong. purpuratus XP_790625 763 85522 L735 L V E T A V L L G S F A K G T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.9 N.A. 68.6 N.A. 91.9 92.1 N.A. 48 76.4 28.5 61.4 N.A. 37.3 37.2 26.3 33.2
Protein Similarity: 100 97.9 N.A. 72 N.A. 96.3 96.3 N.A. 50 87.2 44.7 74.8 N.A. 54.2 53 43.4 51.5
P-Site Identity: 100 100 N.A. 0 N.A. 6.6 6.6 N.A. 6.6 93.3 13.3 6.6 N.A. 20 20 0 6.6
P-Site Similarity: 100 100 N.A. 13.3 N.A. 26.6 26.6 N.A. 13.3 100 20 6.6 N.A. 26.6 26.6 20 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 24 8 16 24 8 0 0 0 8 8 0 8 0 8 8 % A
% Cys: 8 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 8 0 24 8 8 39 0 8 16 16 8 16 % D
% Glu: 8 0 8 0 24 0 0 16 8 8 8 0 8 8 8 % E
% Phe: 0 0 0 24 0 0 16 0 0 0 8 0 8 0 8 % F
% Gly: 0 8 8 0 0 8 8 0 24 8 0 8 0 8 0 % G
% His: 0 0 0 0 0 8 8 0 0 31 0 0 24 0 0 % H
% Ile: 0 0 8 0 0 8 0 0 8 0 0 8 0 0 0 % I
% Lys: 8 31 0 0 39 8 8 8 0 0 0 8 8 0 0 % K
% Leu: 16 0 0 8 0 8 47 16 0 16 24 0 8 8 0 % L
% Met: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % N
% Pro: 8 8 8 8 0 8 0 16 0 8 31 0 0 24 0 % P
% Gln: 0 0 0 8 0 0 0 0 8 0 0 0 0 0 0 % Q
% Arg: 0 8 0 8 0 0 0 0 0 0 0 8 8 31 16 % R
% Ser: 24 8 31 0 16 16 0 0 0 8 0 8 0 0 24 % S
% Thr: 0 8 0 8 0 0 0 31 0 8 16 0 24 8 8 % T
% Val: 8 16 0 0 8 8 8 0 0 8 0 31 0 0 16 % V
% Trp: 0 8 8 0 8 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 8 0 0 0 0 8 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _