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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ADAM17 All Species: 18.48
Human Site: Y379 Identified Species: 33.89
UniProt: P78536 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P78536 NP_003174.3 824 93021 Y379 P V G K K N I Y L N S G L T S
Chimpanzee Pan troglodytes XP_001154844 807 90985 Y379 P V G K K N I Y L N S G L T S
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532870 787 87680 Y358 E C D P G I M Y L N N D T C C
Cat Felis silvestris
Mouse Mus musculus Q9Z0F8 827 93055 Y379 P T V K K N I Y L N S G L T S
Rat Rattus norvegicus Q9Z1K9 827 92999 Y379 P G V K K N I Y L N S G L T S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516484 430 47905 H25 K L L V V A D H R F Y K Y M G
Chicken Gallus gallus NP_001008682 829 93588 Y379 P I V K K D I Y L N S G L T S
Frog Xenopus laevis Q8JIY1 749 84049 S341 V G A P S G S S G G I C E R N
Zebra Danio Brachydanio rerio XP_689147 838 93831 G380 R A I Y L N T G L T S T K N Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VAC5 732 83062 C328 E Y S H K D F C L A H L F T D
Honey Bee Apis mellifera XP_623993 716 82155 K312 F S R E Y S H K D F C L A H L
Nematode Worm Caenorhab. elegans NP_509318 686 77280 R282 W E V E R L L R E F A F A E G
Sea Urchin Strong. purpuratus XP_790625 763 85522 L357 G N G K R Q Y L N T G L T T T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.9 N.A. 68.6 N.A. 91.9 92.1 N.A. 48 76.4 28.5 61.4 N.A. 37.3 37.2 26.3 33.2
Protein Similarity: 100 97.9 N.A. 72 N.A. 96.3 96.3 N.A. 50 87.2 44.7 74.8 N.A. 54.2 53 43.4 51.5
P-Site Identity: 100 100 N.A. 20 N.A. 86.6 86.6 N.A. 0 80 0 20 N.A. 20 0 0 20
P-Site Similarity: 100 100 N.A. 33.3 N.A. 86.6 86.6 N.A. 13.3 93.3 6.6 20 N.A. 26.6 13.3 26.6 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 0 0 8 0 0 0 8 8 0 16 0 0 % A
% Cys: 0 8 0 0 0 0 0 8 0 0 8 8 0 8 8 % C
% Asp: 0 0 8 0 0 16 8 0 8 0 0 8 0 0 8 % D
% Glu: 16 8 0 16 0 0 0 0 8 0 0 0 8 8 0 % E
% Phe: 8 0 0 0 0 0 8 0 0 24 0 8 8 0 0 % F
% Gly: 8 16 24 0 8 8 0 8 8 8 8 39 0 0 16 % G
% His: 0 0 0 8 0 0 8 8 0 0 8 0 0 8 0 % H
% Ile: 0 8 8 0 0 8 39 0 0 0 8 0 0 0 0 % I
% Lys: 8 0 0 47 47 0 0 8 0 0 0 8 8 0 0 % K
% Leu: 0 8 8 0 8 8 8 8 62 0 0 24 39 0 8 % L
% Met: 0 0 0 0 0 0 8 0 0 0 0 0 0 8 0 % M
% Asn: 0 8 0 0 0 39 0 0 8 47 8 0 0 8 8 % N
% Pro: 39 0 0 16 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % Q
% Arg: 8 0 8 0 16 0 0 8 8 0 0 0 0 8 0 % R
% Ser: 0 8 8 0 8 8 8 8 0 0 47 0 0 0 39 % S
% Thr: 0 8 0 0 0 0 8 0 0 16 0 8 16 54 8 % T
% Val: 8 16 31 8 8 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 8 8 0 8 47 0 0 8 0 8 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _