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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ADAM17 All Species: 22.73
Human Site: Y433 Identified Species: 41.67
UniProt: P78536 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P78536 NP_003174.3 824 93021 Y433 N E D Q G G K Y V M Y P I A V
Chimpanzee Pan troglodytes XP_001154844 807 90985 Y433 N E D Q G G K Y V M Y P I A V
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532870 787 87680 A400 A Q K K C Q E A I N A T C K G
Cat Felis silvestris
Mouse Mus musculus Q9Z0F8 827 93055 Y433 N E D Q G G K Y V M Y P I A V
Rat Rattus norvegicus Q9Z1K9 827 92999 Y433 N E D Q G G K Y V M Y P I A V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516484 430 47905 G66 W D N A G F K G Y G I Q I E Q
Chicken Gallus gallus NP_001008682 829 93588 Y433 T E D Q G G K Y V M Y P I A V
Frog Xenopus laevis Q8JIY1 749 84049 T381 P P K V S H I T F A H E V G H
Zebra Danio Brachydanio rerio XP_689147 838 93831 Y430 R E D Q G G K Y V M Y P I A V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VAC5 732 83062 G368 T P E Y F K N G Y T L Y L N S
Honey Bee Apis mellifera XP_623993 716 82155 F352 G I C T P E Y F K N G Y T L Y
Nematode Worm Caenorhab. elegans NP_509318 686 77280 E322 V S Y K K W D E T A G G I C S
Sea Urchin Strong. purpuratus XP_790625 763 85522 G398 E H D P G N E G D E C A P G N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.9 N.A. 68.6 N.A. 91.9 92.1 N.A. 48 76.4 28.5 61.4 N.A. 37.3 37.2 26.3 33.2
Protein Similarity: 100 97.9 N.A. 72 N.A. 96.3 96.3 N.A. 50 87.2 44.7 74.8 N.A. 54.2 53 43.4 51.5
P-Site Identity: 100 100 N.A. 0 N.A. 100 100 N.A. 20 93.3 0 93.3 N.A. 0 0 6.6 13.3
P-Site Similarity: 100 100 N.A. 26.6 N.A. 100 100 N.A. 33.3 93.3 13.3 93.3 N.A. 13.3 6.6 13.3 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 8 0 0 0 8 0 16 8 8 0 47 0 % A
% Cys: 0 0 8 0 8 0 0 0 0 0 8 0 8 8 0 % C
% Asp: 0 8 54 0 0 0 8 0 8 0 0 0 0 0 0 % D
% Glu: 8 47 8 0 0 8 16 8 0 8 0 8 0 8 0 % E
% Phe: 0 0 0 0 8 8 0 8 8 0 0 0 0 0 0 % F
% Gly: 8 0 0 0 62 47 0 24 0 8 16 8 0 16 8 % G
% His: 0 8 0 0 0 8 0 0 0 0 8 0 0 0 8 % H
% Ile: 0 8 0 0 0 0 8 0 8 0 8 0 62 0 0 % I
% Lys: 0 0 16 16 8 8 54 0 8 0 0 0 0 8 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 8 0 8 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 47 0 0 0 0 0 % M
% Asn: 31 0 8 0 0 8 8 0 0 16 0 0 0 8 8 % N
% Pro: 8 16 0 8 8 0 0 0 0 0 0 47 8 0 0 % P
% Gln: 0 8 0 47 0 8 0 0 0 0 0 8 0 0 8 % Q
% Arg: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 8 0 0 8 0 0 0 0 0 0 0 0 0 16 % S
% Thr: 16 0 0 8 0 0 0 8 8 8 0 8 8 0 0 % T
% Val: 8 0 0 8 0 0 0 0 47 0 0 0 8 0 47 % V
% Trp: 8 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 8 0 0 8 47 16 0 47 16 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _