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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ADAM17 All Species: 22.73
Human Site: Y436 Identified Species: 41.67
UniProt: P78536 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P78536 NP_003174.3 824 93021 Y436 Q G G K Y V M Y P I A V S G D
Chimpanzee Pan troglodytes XP_001154844 807 90985 Y436 Q G G K Y V M Y P I A V S G D
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532870 787 87680 A403 K C Q E A I N A T C K G V S Y
Cat Felis silvestris
Mouse Mus musculus Q9Z0F8 827 93055 Y436 Q G G K Y V M Y P I A V S G D
Rat Rattus norvegicus Q9Z1K9 827 92999 Y436 Q G G K Y V M Y P I A V S G D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516484 430 47905 I69 A G F K G Y G I Q I E Q I R I
Chicken Gallus gallus NP_001008682 829 93588 Y436 Q G G K Y V M Y P I A V S G D
Frog Xenopus laevis Q8JIY1 749 84049 H384 V S H I T F A H E V G H N F G
Zebra Danio Brachydanio rerio XP_689147 838 93831 Y433 Q G G K Y V M Y P I A V S G D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VAC5 732 83062 L371 Y F K N G Y T L Y L N S G L S
Honey Bee Apis mellifera XP_623993 716 82155 G355 T P E Y F K N G Y T L Y L N S
Nematode Worm Caenorhab. elegans NP_509318 686 77280 G325 K K W D E T A G G I C S K Q E
Sea Urchin Strong. purpuratus XP_790625 763 85522 C401 P G N E G D E C A P G N S R G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.9 N.A. 68.6 N.A. 91.9 92.1 N.A. 48 76.4 28.5 61.4 N.A. 37.3 37.2 26.3 33.2
Protein Similarity: 100 97.9 N.A. 72 N.A. 96.3 96.3 N.A. 50 87.2 44.7 74.8 N.A. 54.2 53 43.4 51.5
P-Site Identity: 100 100 N.A. 0 N.A. 100 100 N.A. 20 100 0 100 N.A. 0 0 6.6 13.3
P-Site Similarity: 100 100 N.A. 20 N.A. 100 100 N.A. 20 100 20 100 N.A. 6.6 6.6 20 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 8 0 16 8 8 0 47 0 0 0 0 % A
% Cys: 0 8 0 0 0 0 0 8 0 8 8 0 0 0 0 % C
% Asp: 0 0 0 8 0 8 0 0 0 0 0 0 0 0 47 % D
% Glu: 0 0 8 16 8 0 8 0 8 0 8 0 0 0 8 % E
% Phe: 0 8 8 0 8 8 0 0 0 0 0 0 0 8 0 % F
% Gly: 0 62 47 0 24 0 8 16 8 0 16 8 8 47 16 % G
% His: 0 0 8 0 0 0 0 8 0 0 0 8 0 0 0 % H
% Ile: 0 0 0 8 0 8 0 8 0 62 0 0 8 0 8 % I
% Lys: 16 8 8 54 0 8 0 0 0 0 8 0 8 0 0 % K
% Leu: 0 0 0 0 0 0 0 8 0 8 8 0 8 8 0 % L
% Met: 0 0 0 0 0 0 47 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 8 0 0 16 0 0 0 8 8 8 8 0 % N
% Pro: 8 8 0 0 0 0 0 0 47 8 0 0 0 0 0 % P
% Gln: 47 0 8 0 0 0 0 0 8 0 0 8 0 8 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 16 0 % R
% Ser: 0 8 0 0 0 0 0 0 0 0 0 16 54 8 16 % S
% Thr: 8 0 0 0 8 8 8 0 8 8 0 0 0 0 0 % T
% Val: 8 0 0 0 0 47 0 0 0 8 0 47 8 0 0 % V
% Trp: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 8 47 16 0 47 16 0 0 8 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _