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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NTHL1 All Species: 30.3
Human Site: S135 Identified Species: 51.28
UniProt: P78549 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P78549 NP_002519.1 312 34390 S135 R R Y Q V L L S L M L S S Q T
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001082772 312 34406 S135 R R Y Q V L L S L M L S S Q T
Dog Lupus familis XP_853674 312 34244 S135 Q R Y Q V L L S L M L S S Q T
Cat Felis silvestris
Mouse Mus musculus O35980 300 33628 S123 R R Y Q V L L S L M L S S Q T
Rat Rattus norvegicus O70249 345 38693 S115 Q L Y S H W A S V D S H F Q S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517653 262 28773 R111 G V E Q C F D R D A P P E V Q
Chicken Gallus gallus NP_001073043 281 31866 S104 M R Y Q V L L S L M L S S Q T
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001346643 430 48207 S173 R R Y Q V L I S L M L S S Q T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_610078 388 43493 A202 Q R F Q N L V A L M L S S Q T
Honey Bee Apis mellifera XP_623602 321 36892 A136 A R Y Q S L I A L M L S S Q T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_793669 395 44330 S198 Y R Y H V L L S L M L S S Q T
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001151454 364 40315 T168 R F A V L I S T M M S S Q T K
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_001077988 377 41467 A178 R F A V L L G A L L S S Q T K
Baker's Yeast Sacchar. cerevisiae P31378 399 45558 D158 M L S S Q T K D E V T A M A M
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 93.9 79.4 N.A. 78.8 20.8 N.A. 50.9 63.4 N.A. 42.7 N.A. 40.7 46.1 N.A. 43.5
Protein Similarity: 100 N.A. 95.5 86.2 N.A. 84.9 33 N.A. 60.5 73.4 N.A. 52.3 N.A. 53 59.5 N.A. 56.9
P-Site Identity: 100 N.A. 100 93.3 N.A. 100 20 N.A. 6.6 93.3 N.A. 93.3 N.A. 66.6 73.3 N.A. 86.6
P-Site Similarity: 100 N.A. 100 100 N.A. 100 40 N.A. 6.6 93.3 N.A. 100 N.A. 93.3 86.6 N.A. 86.6
Percent
Protein Identity: N.A. 38.7 N.A. 38.4 31 N.A.
Protein Similarity: N.A. 53.3 N.A. 52.5 43.8 N.A.
P-Site Identity: N.A. 20 N.A. 26.6 0 N.A.
P-Site Similarity: N.A. 46.6 N.A. 46.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 15 0 0 0 8 22 0 8 0 8 0 8 0 % A
% Cys: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 8 8 8 8 0 0 0 0 0 % D
% Glu: 0 0 8 0 0 0 0 0 8 0 0 0 8 0 0 % E
% Phe: 0 15 8 0 0 8 0 0 0 0 0 0 8 0 0 % F
% Gly: 8 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 8 8 0 0 0 0 0 0 8 0 0 0 % H
% Ile: 0 0 0 0 0 8 15 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 15 % K
% Leu: 0 15 0 0 15 72 43 0 72 8 65 0 0 0 0 % L
% Met: 15 0 0 0 0 0 0 0 8 72 0 0 8 0 8 % M
% Asn: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 8 8 0 0 0 % P
% Gln: 22 0 0 65 8 0 0 0 0 0 0 0 15 72 8 % Q
% Arg: 43 65 0 0 0 0 0 8 0 0 0 0 0 0 0 % R
% Ser: 0 0 8 15 8 0 8 58 0 0 22 79 65 0 8 % S
% Thr: 0 0 0 0 0 8 0 8 0 0 8 0 0 15 65 % T
% Val: 0 8 0 15 50 0 8 0 8 8 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 65 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _