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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NTHL1
All Species:
18.48
Human Site:
S163
Identified Species:
31.28
UniProt:
P78549
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78549
NP_002519.1
312
34390
S163
A
R
G
L
T
V
D
S
I
L
Q
T
D
D
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001082772
312
34406
S163
A
Q
G
L
T
V
D
S
I
L
Q
T
D
D
A
Dog
Lupus familis
XP_853674
312
34244
S163
A
H
G
L
T
V
D
S
I
L
Q
T
D
D
A
Cat
Felis silvestris
Mouse
Mus musculus
O35980
300
33628
S151
A
R
G
L
T
V
E
S
I
L
Q
T
D
D
D
Rat
Rattus norvegicus
O70249
345
38693
S143
D
P
T
E
C
L
F
S
F
I
C
S
S
N
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517653
262
28773
G139
T
K
D
Q
V
T
A
G
A
M
R
R
L
Q
A
Chicken
Gallus gallus
NP_001073043
281
31866
S132
Q
R
G
L
T
V
D
S
I
L
Q
M
D
D
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001346643
430
48207
G201
E
H
G
L
S
V
D
G
I
L
K
M
D
D
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610078
388
43493
K230
D
R
G
L
T
P
L
K
V
K
E
M
P
V
T
Honey Bee
Apis mellifera
XP_623602
321
36892
I164
T
Y
G
C
T
P
E
I
I
A
G
T
P
D
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793669
395
44330
N226
S
H
G
L
T
V
D
N
I
L
K
T
P
E
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001151454
364
40315
A196
N
G
L
L
D
P
D
A
I
V
R
T
D
E
T
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_001077988
377
41467
A206
N
G
L
L
T
P
E
A
V
D
K
A
D
E
S
Baker's Yeast
Sacchar. cerevisiae
P31378
399
45558
A186
E
E
G
M
T
L
E
A
V
L
Q
I
N
E
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
93.9
79.4
N.A.
78.8
20.8
N.A.
50.9
63.4
N.A.
42.7
N.A.
40.7
46.1
N.A.
43.5
Protein Similarity:
100
N.A.
95.5
86.2
N.A.
84.9
33
N.A.
60.5
73.4
N.A.
52.3
N.A.
53
59.5
N.A.
56.9
P-Site Identity:
100
N.A.
93.3
93.3
N.A.
86.6
6.6
N.A.
6.6
86.6
N.A.
53.3
N.A.
26.6
33.3
N.A.
60
P-Site Similarity:
100
N.A.
100
93.3
N.A.
93.3
33.3
N.A.
26.6
86.6
N.A.
66.6
N.A.
40
40
N.A.
86.6
Percent
Protein Identity:
N.A.
38.7
N.A.
38.4
31
N.A.
Protein Similarity:
N.A.
53.3
N.A.
52.5
43.8
N.A.
P-Site Identity:
N.A.
33.3
N.A.
20
26.6
N.A.
P-Site Similarity:
N.A.
60
N.A.
60
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
29
0
0
0
0
0
8
22
8
8
0
8
0
0
43
% A
% Cys:
0
0
0
8
8
0
0
0
0
0
8
0
0
0
0
% C
% Asp:
15
0
8
0
8
0
50
0
0
8
0
0
58
50
15
% D
% Glu:
15
8
0
8
0
0
29
0
0
0
8
0
0
29
8
% E
% Phe:
0
0
0
0
0
0
8
0
8
0
0
0
0
0
0
% F
% Gly:
0
15
72
0
0
0
0
15
0
0
8
0
0
0
0
% G
% His:
0
22
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
8
65
8
0
8
0
0
0
% I
% Lys:
0
8
0
0
0
0
0
8
0
8
22
0
0
0
0
% K
% Leu:
0
0
15
72
0
15
8
0
0
58
0
0
8
0
0
% L
% Met:
0
0
0
8
0
0
0
0
0
8
0
22
0
0
0
% M
% Asn:
15
0
0
0
0
0
0
8
0
0
0
0
8
8
8
% N
% Pro:
0
8
0
0
0
29
0
0
0
0
0
0
22
0
0
% P
% Gln:
8
8
0
8
0
0
0
0
0
0
43
0
0
8
0
% Q
% Arg:
0
29
0
0
0
0
0
0
0
0
15
8
0
0
0
% R
% Ser:
8
0
0
0
8
0
0
43
0
0
0
8
8
0
8
% S
% Thr:
15
0
8
0
72
8
0
0
0
0
0
50
0
0
22
% T
% Val:
0
0
0
0
8
50
0
0
22
8
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _